Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Apr 6;13(4):625.
doi: 10.3390/v13040625.

Intervention Strategies for Seasonal and Emerging Respiratory Viruses with Drugs and Vaccines Targeting Viral Surface Glycoproteins

Ralph A Tripp  1 , John Stambas  2
Affiliations
Review

Intervention Strategies for Seasonal and Emerging Respiratory Viruses with Drugs and Vaccines Targeting Viral Surface Glycoproteins

Ralph A Tripp et al. Viruses. .

Abstract

Vaccines and therapeutics targeting viral surface glycoproteins are a major component of disease prevention for respiratory viral diseases. Over the years, vaccines have proven to be the most successful intervention for preventing disease. Technological advances in vaccine platforms that focus on viral surface glycoproteins have provided solutions for current and emerging pathogens like SARS-CoV-2, and our understanding of the structural basis for antibody neutralization is guiding the selection of other vaccine targets for respiratory viruses like RSV. This review discusses the role of viral surface glycoproteins in disease intervention approaches.

Keywords: RSV; SARS-CoV-2; respiratory syncytial virus; respiratory virus; therapeutics; vaccines.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Similar articles

See all similar articles

Cited by

References

    1. Wang X., Li Y., O’Brien K.L., Madhi S.A., Widdowson M.A., Byass P., Omer S.B., Abbas Q., Ali A., Amu A., et al. Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: A systematic review and modelling study. Lancet Glob. Health. 2020;8:e497–e510. doi: 10.1016/S2214-109X(19)30545-5. - DOI - PMC - PubMed
    1. Shi T., Arnott A., Semogas I., Falsey A.R., Openshaw P., Wedzicha J.A., Campbell H., Nair H., Investigators R. The etiological role of common respiratory viruses in acute respiratory infections in older adults: A systematic review and meta-analysis. J. Infect. Dis. 2020;222:S563–S569. doi: 10.1093/infdis/jiy662. - DOI - PMC - PubMed
    1. West J.V. Acute upper airway infections. Br. Med. Bull. 2002;61:215–230. doi: 10.1093/bmb/61.1.215. - DOI - PMC - PubMed
    1. Chatterjee A., Mavunda K., Krilov L.R. Current state of respiratory syncytial virus disease and management. Infect. Dis. Ther. 2021;3:1–12. - PMC - PubMed
    1. Tin Tin Htar M., Yerramalla M.S., Moisi J.C., Swerdlow D.L. The burden of respiratory syncytial virus in adults: A systematic review and meta-analysis. Epidemiol. Infect. 2020;148:e48. doi: 10.1017/S0950268820000400. - DOI - PMC - PubMed

LinkOut - more resources