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Review
. 2021 Apr 9;13(8):1791.
doi: 10.3390/cancers13081791.

MR-Guided Hypofractionated Radiotherapy: Current Emerging Data and Promising Perspectives for Localized Prostate Cancer

Francesco Cuccia  1 , Stefanie Corradini  2 , Rosario Mazzola  1 , Luigi Spiazzi  3 , Michele Rigo  1 , Marco Lorenzo Bonù  4   5 , Ruggero Ruggieri  1 , Michela Buglione di Monale E Bastia  4   5 , Stefano Maria Magrini  4   5 , Filippo Alongi  1   5
Affiliations
Review

MR-Guided Hypofractionated Radiotherapy: Current Emerging Data and Promising Perspectives for Localized Prostate Cancer

Francesco Cuccia et al. Cancers (Basel). .

Abstract

In this review we summarize the currently available evidence about the role of hybrid machines for MR-guided radiotherapy for prostate stereotactic body radiotherapy. Given the novelty of this technology, to date few data are accessible, but they all report very promising results in terms of tolerability and preliminary clinical outcomes. Most of the studies highlight the favorable impact of on-board magnetic resonance imaging as a means to improve target and organs at risk identification with a consequent advantage in terms of dosimetric results, which is expected to relate to a more favorable toxicity pattern. Still, the longer treatment time per session may potentially affect the patient's compliance to the treatment, although first quality of life assessment studies have reported substantial tolerability and no major impact on quality of life. Finally, in this review we hypothesize some future scenarios of further investigation, based on the possibility to explore the superior anatomy visualization and the role of daily adapted treatments provided by hybrid MR-Linacs.

Keywords: mr-guided radiotherapy; prostate cancer; stereotactic body radiotherapy.

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Conflict of interest statement

F.A. acts as an Elekta consultant and he had speaker honoraria. R.R. is a consultant for Elekta. The remaining authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
Daily replanning for Magnetic Resonance-guided Stereotactic Body Radiotherapy (MR-guided SBRT).
Figure 2
Figure 2
Daily interfraction variability of Planning Target Volume (PTV) and bladder.
Figure 3
Figure 3
Cine Magnetic Resonance (CineMR) sequence before the delivery of MR-guided SBRT.
Figure 4
Figure 4
Sexual preservation during MR-guided prostate SBRT (blue arrows indicate the prostate neurovascular plexus).
See this image and copyright information in PMC

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