[B-lymphocyte origin of the Reed-Sternberg cell. Immunoelectronmicroscopical arguments (author's transl)]

Abstract

Some direct and indirect arguments are at present in favour of the B-lymphocyte origin of the Reed-Sternberg (R.S.) cell. Immunoperoxidase methods applied to paraffin sections permit to identify immunoglobulin components in their cytoplasm, but these results are not suffisant to prove that the R.S. cell synthesizes immunoglobulins. We have applied immunoelectronmicroscopic methods to a lymph node in a case of Hodgkin's disease. The results permit us to found intracellular immunoglobulins in the R.S. cell and to evoke a probable synthesis of immunoglobulin by free ribosomes, thus agreing the B-lymphocyte nature hypothesis of the R.S. cell.