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Review
. 2021 Apr 10;10(4):317.
doi: 10.3390/biology10040317.

Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation-A Narrative Review

Eitan Mijiritsky  1   2 , Haya Drora Assaf  3 , Oren Peleg  1 , Maayan Shacham  4 , Loredana Cerroni  5 , Luca Mangani  5
Affiliations
Review

Use of PRP, PRF and CGF in Periodontal Regeneration and Facial Rejuvenation-A Narrative Review

Eitan Mijiritsky et al. Biology (Basel). .

Abstract

Growth factors (GFs) play a vital role in cell proliferation, migration, differentiation and angiogenesis. Autologous platelet concentrates (APCs) which contain high levels of GFs make them especially suitable for periodontal regeneration and facial rejuvenation. The main generations of APCs presented are platelet-rich plasma (PRP), platelet-rich fibrin (PRF) and concentrated growth factor (CGF) techniques. The purpose of this review is to provide the clinician with an overview of APCs' evolution over the past decade in order to give reliable and useful information to be used in clinical work. This review summarizes the most interesting and novel articles published between 1997 and 2020. Electronic and manual searches were conducted in the following databases: Pubmed, Scopus, Cochrane Library and Embase. The following keywords were used: growth factors, VEGF, TGF-b1, PRP, PRF, CGF and periodontal regeneration and/or facial rejuvenation. A total of 73 articles were finally included. The review then addresses the uses of the three different techniques in the two disciplines, as well as the advantages and limitations of each technique. Overall, PRP is mainly used in cases of hard and soft tissue procedures, while PRF is used in gingival recession and the treatment of furcation and intrabony defects; CGF is mainly used in bone regeneration.

Keywords: CGF; PRF; PRP; autologous platelet concentrates; facial rejuvenation; periodontal regeneration.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Blood centrifugation after collection. After the first centrifugation period, there is a separation of two layers: on top—platelet-poor plasma (PPP), on bottom—red blood cells (RBCs) and buffy coat. The products of the second centrifugation period are: top—PPP; bottom—buffy coat (PRP) and residual RBCs.
Figure 2
Figure 2
Blood centrifugation after collection. The layers after centrifugation period are: on bottom—RBCs, middle layer—fibrin clot layer (PRF) and on top—PPP.
Figure 3
Figure 3
Blood centrifugation after collection. At the end of the centrifugation period, four layers are obtained: 1. Bottom—RBC layer; 2. GF and stem cell layer (CGF); 3. Buffy coat layer; 4. Top—serum layer (PPP).
Figure 4
Figure 4
Flowchart of the search strategy.
See this image and copyright information in PMC

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