Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 17;10(8):1748.
doi: 10.3390/jcm10081748.

A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis

Cécilia Bec  1 , Axelle Rousset  1 , Thibault Brandin  1 , Pauline François  1   2 , Sitraka Rabarimeriarijaona  1 , Chloé Dumoulin  1 , Gaëlle Heleu  1 , Fanny Grimaud  1 , Julie Veran  1 , Guy Magalon  3 , Françoise Dignat-George  2   4 , Florence Sabatier  1   2   3 , Marie-Laure Louis  5   6   7 , Jérémy Magalon  1   2   3
Affiliations

A Retrospective Analysis of Characteristic Features of Responders and Impaired Patients to a Single Injection of Pure Platelet-Rich Plasma in Knee Osteoarthritis

Cécilia Bec et al. J Clin Med. .

Abstract

(1) Background: The emergence of injectable "biologic" medication creates a new approach to treat osteoarthritis (OA). Among them, the use of intra-articular injection of PRP became widespread despite the absence of consensus regarding its optimal composition. The aim of this study was to retrospectively correlate an extensive biological characterization of injected PRP to the clinical responses of patients presenting knee OA. (2) Methods: This retrospective study included 75 patients with knee OA. Cartilage lesions were assessed using magnetic resonance imaging and the International Cartilage Regeneration Society (ICRS) classification. PRP extensive biological characterization was performed and patients' subjective symptoms were recorded before injection and 3 and 6 months after injection using the Knee injury and Osteoarthritis Outcome Score (KOOS). Responders were defined by an improvement of 10 points on KOOS. (3) Results: At 6 months, 63.0% of the patients were responders. Impairment was characterized by a significantly higher proportion of patients with three compartments altered at baseline MRI and receiving a significantly higher dose of platelets compared to responders. (4) Conclusions: Single injection of pure PRP resulted in significant clinical improvement in the management of knee OA. Both baseline MRI and PRP biological features may be predictive factors of the clinical response, highlighting that a better understanding of action mechanism of PRP is still required.

Keywords: KOOS score; biological characterization; growth factors; knee osteoarthritis; platelet-rich plasma.

PubMed Disclaimer

Conflict of interest statement

G.M., F.S. and J.M. are co-founders of REMEDEX. J.M. received honorarium for educational support from FIDIA, HORIBA and MACOPHARMA. These manufacturers had no role in the redaction of this manuscript or its decision for publication.

Figures

Figure 1
Figure 1
Comparison of Knee injury and Osteoarthritis Outcome Score (KOOS) score after platelet-rich plasma (PRP) injection between responders and impaired patients (*, p < 0.05; **, p < 0.01; *** p < 0.001).
Figure 2
Figure 2
Comparison of dose of platelets injected between responders and impaired patients (p = 0.01). Green circles represent responder’s patients and red squares represent impaired patients.
See this image and copyright information in PMC

References

    1. Glyn-Jones S., Palmer A.J., Agricola R., Price A.J., Vincent T.L., Weinans H., Carr A.J. Osteoarthritis. Lancet. 2015;386:376–387. doi: 10.1016/S0140-6736(14)60802-3. - DOI - PubMed
    1. James S.L., Abate D., Abate K.H., Abay S.M., Abbafati C., Abbasi N., Abbastabar H., Abd-Allah F., Abdela J., Abdelalim A. Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990–2017: A systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1789–1858. doi: 10.1016/S0140-6736(18)32279-7. - DOI - PMC - PubMed
    1. Mobasheri A., Batt M. An update on the pathophysiology of osteoarthritis. Ann. Phys. Rehabil. Med. 2016;59:333–339. doi: 10.1016/j.rehab.2016.07.004. - DOI - PubMed
    1. Hussain S., Neilly D., Baliga S., Patil S., Meek R. Knee osteoarthritis: A review of management options. Scott. Med. J. 2016;61:7–16. doi: 10.1177/0036933015619588. - DOI - PubMed
    1. Herrero-Beaumont G., Roman-Blas J.A., Bruyère O., Cooper C., Kanis J., Maggi S., Rizzoli R., Reginster J.-Y. Clinical settings in knee osteoarthritis: Pathophysiology guides treatment. Maturitas. 2017;96:54–57. doi: 10.1016/j.maturitas.2016.11.013. - DOI - PubMed

LinkOut - more resources