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Editorial
. 2021 Apr 15;22(8):4080.
doi: 10.3390/ijms22084080.

Immunopathology of Atherosclerosis and Related Diseases: Focus on Molecular Biology

Evgeny E Bezsonov  1   2   3 , Igor A Sobenin  1   4 , Alexander N Orekhov  1   2
Affiliations
Editorial

Immunopathology of Atherosclerosis and Related Diseases: Focus on Molecular Biology

Evgeny E Bezsonov et al. Int J Mol Sci. .

Abstract

In this Special Issue of the International Journal of Molecular Sciences, we include insightful reviews and research papers on the subject "Immunopathology of Atherosclerosis and Related Diseases: Focus on Molecular Biology".[...].

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The model of atherosclerosis development due to chronic inflammation induced by a combination of recognition errors of modified low-density lipoproteins (LDLs) as pathogens and impaired mitophagy. Modified LDLs form self-associates and are identified by arterial cells as pathogens. After phagocytosis of LDL associates, a moderate inflammatory response is activated, leading to moderate intracellular lipid accumulation and moderate atherogenesis and the damage can still be repaired. However, in case of impaired mitophagy due to mitochondrial mutations, the inflammatory response, once being activated by modified LDL, does not stop and the inflammation becomes uncontrollable, leading to massive intracellular lipids accumulation, infiltration of immune cells, and strong atherogenesis. Modified and adapted from [15].
See this image and copyright information in PMC

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