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Review
. 2021 Apr 22;11(5):623.
doi: 10.3390/biom11050623.

Regulation of Long Non-Coding RNAs by Statins in Atherosclerosis

Diamantis I Tsilimigras  1 , Sofia-Iris Bibli  2 , Gerasimos Siasos  3 , Evangelos Oikonomou  3 , Despina N Perrea  4 , Konstantinos Filis  1 , Dimitrios Tousoulis  3 , Fragiska Sigala  1
Affiliations
Review

Regulation of Long Non-Coding RNAs by Statins in Atherosclerosis

Diamantis I Tsilimigras et al. Biomolecules. .

Abstract

Despite increased public health awareness, atherosclerosis remains a leading cause of mortality worldwide. Significant variations in response to statin treatment have been noted among different populations suggesting that the efficacy of statins may be altered by both genetic and environmental factors. The existing literature suggests that certain long noncoding RNAs (lncRNAs) might be up- or downregulated among patients with atherosclerosis. LncRNA may act on multiple levels (cholesterol homeostasis, vascular inflammation, and plaque destabilization) and exert atheroprotective or atherogenic effects. To date, only a few studies have investigated the interplay between statins and lncRNAs known to be implicated in atherosclerosis. The current review characterizes the role of lncRNAs in atherosclerosis and summarizes the available evidence related to the effect of statins in regulating lncRNAs.

Keywords: RNA; epigenetics; statin; vascular biology.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
LncRNAs implicated in atherosclerosis (atheroprotective or atherogenic). Reproduced from Josefs et al. Curr. Atheroscler. Rep. 2020, 22, 55, doi:10.1007/s11883-020-00872-6 [9]; Creative Commons User License. Available online: https://creativecommons.org/licenses/by/4.0 (accessed on 12 April 2021).
See this image and copyright information in PMC

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