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Review
. 2021 Apr 23;22(9):4412.
doi: 10.3390/ijms22094412.

Functionalization of Synthetic Bone Substitutes

André Busch  1   2 , Marcus Jäger  1   3 , Constantin Mayer  1 , Andrea Sowislok  2
Affiliations
Review

Functionalization of Synthetic Bone Substitutes

André Busch et al. Int J Mol Sci. .

Abstract

Bone substitutes have been applied to treat osseous defects for a long time. To prevent implant related infection (IRI) and enhance bone healing functionalized biomaterials, antibiotics and osteoinductive substances have been introduced. This study gives an overview of the current available surface-coated bone substitutes and provides an outlook for future perspectives.

Keywords: BMP; antibiotics; implant related infections; tissue engineering.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Macroscopic and microscopic pictures of a PDLLA fleece made by electro spinning as an example for a tissue-engineered biomaterial for growth factor delivery. (A) Macroscopic photo of a polylactide fleece made by electro spinning. (B) SEM image reveals typical non-woven, fibrous structure with random orientation. (C) TEM image shows iron containing ferritin molecules adsorbed on the fiber surface. (unpublished results from symposium presentation [54]).
Figure 2
Figure 2
Illustrates a CAD-model of a suction handle for intraoperative stromal cell enrichment filled with a ceramic scaffold (©EFRE-Projekt Boneflo, Department of Orthopaedics and Trauma Surgery University of Duisburg-Essen, Germany).
Figure 3
Figure 3
Shows a ß-TCP ceramic scaffold after intraoperative augmentation with cell-tissue composite (EFRE-Projekt Boneflo, Department of Orthopaedics and Trauma Surgery University of Duisburg-Essen, Germany).
See this image and copyright information in PMC

References

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