Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Apr 25;22(9):4470.
doi: 10.3390/ijms22094470.

Candida auris: A Quick Review on Identification, Current Treatments, and Challenges

Lucia Černáková  1 , Maryam Roudbary  2 , Susana Brás  3 , Silva Tafaj  4 , Célia F Rodrigues  5
Affiliations
Review

Candida auris: A Quick Review on Identification, Current Treatments, and Challenges

Lucia Černáková et al. Int J Mol Sci. .

Abstract

Candida auris is a novel and major fungal pathogen that has triggered several outbreaks in the last decade. The few drugs available to treat fungal diseases, the fact that this yeast has a high rate of multidrug resistance and the occurrence of misleading identifications, and the ability of forming biofilms (naturally more resistant to drugs) has made treatments of C. auris infections highly difficult. This review intends to quickly illustrate the main issues in C. auris identification, available treatments and the associated mechanisms of resistance, and the novel and alternative treatment and drugs (natural and synthetic) that have been recently reported.

Keywords: Candida auris; antifungal; biofilm; infection; novel therapy; resistance.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Biochemical-based methods commonly used to identify C. auris and species associated with misidentification issues [34,46,47,48].
Figure 2
Figure 2
Molecular-based methods commonly used to identify C. auris [12,49,50,51,52,53,54,55,56,57,58,59,60,61].
See this image and copyright information in PMC

References

    1. Rodrigues M.E., Gomes F., Rodrigues C.F. Candida spp./Bacteria Mixed Biofilms. J. Fungi. 2019;6:5. doi: 10.3390/jof6010005. - DOI - PMC - PubMed
    1. Barnes R.A., Gow N.A.R., Denning D.W., May R.C., Haynes K. Antifungal resistance: More research needed. Lancet. 2014;384:1427. doi: 10.1016/S0140-6736(14)61861-4. - DOI - PubMed
    1. Misseri G., Ippolito M., Cortegiani A. Global warming “heating up” the ICU through Candida auris infections: The climate changes theory. Crit. Care. 2019;23:416. doi: 10.1186/s13054-019-2702-4. - DOI - PMC - PubMed
    1. Alvarado M., Bartolomé Álvarez J., Lockhart S.R., Valentín E., Ruiz-Gaitán A.C., Eraso E., de Groot P.W.J. Identification of Candida auris and related species by multiplex PCR based on unique GPI protein-encoding genes. Mycoses. 2021;64:194–202. doi: 10.1111/myc.13204. - DOI - PMC - PubMed
    1. Abastabar M., Haghani I., Ahangarkani F., Rezai M.S., Taghizadeh Armaki M., Roodgari S., Kiakojuri K., Al-Hatmi A.M.S., Meis J.F., Badali H. Candida auris otomycosis in Iran and review of recent literature. Mycoses. 2019;62:101–105. doi: 10.1111/myc.12886. - DOI - PubMed