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Review
. 2021 Apr 16;22(8):4110.
doi: 10.3390/ijms22084110.

JDP2, a Novel Molecular Key in Heart Failure and Atrial Fibrillation?

Gerhild Euler  1 , Jens Kockskämper  2 , Rainer Schulz  1 , Mariana S Parahuleva  3
Affiliations
Review

JDP2, a Novel Molecular Key in Heart Failure and Atrial Fibrillation?

Gerhild Euler et al. Int J Mol Sci. .

Abstract

Heart failure (HF) and atrial fibrillation (AF) are two major life-threatening diseases worldwide. Causes and mechanisms are incompletely understood, yet current therapies are unable to stop disease progression. In this review, we focus on the contribution of the transcriptional modulator, Jun dimerization protein 2 (JDP2), and on HF and AF development. In recent years, JDP2 has been identified as a potential prognostic marker for HF development after myocardial infarction. This close correlation to the disease development suggests that JDP2 may be involved in initiation and progression of HF as well as in cardiac dysfunction. Although no studies have been done in humans yet, studies on genetically modified mice impressively show involvement of JDP2 in HF and AF, making it an interesting therapeutic target.

Keywords: atrial fibrillation; heart failure; remodeling; transcription factor.

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Conflict of interest statement

Authors have no conflict to disclose.

Figures

Figure 1
Figure 1
Overview about cardiac JDP2 effects. Summarized are results of studies about JDP2 effects in the heart and isolated cardiomyocytes.
Figure 2
Figure 2
Potential mechanisms contributing to heart failure and atrial fibrillation in JDP2 mice.
See this image and copyright information in PMC

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