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Review
. 2021 Apr 16;10(8):1737.
doi: 10.3390/jcm10081737.

Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers

Dimitrios Kikidis  1 , Evgenia Vassou  1 , Winfried Schlee  2 , Eleftheria Iliadou  1 , Nikolaos Markatos  1 , Aikaterini Triantafyllou  1 , Berthold Langguth  2
Affiliations
Review

Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers

Dimitrios Kikidis et al. J Clin Med. .

Abstract

Although a wide range of tinnitus management interventions is currently under research and a variety of therapeutic interventions have already been applied in clinical practice, no optimal and universal tinnitus treatment has been reached yet. This fact is to some extent a consequence of the high heterogeneity of the methodologies used in tinnitus related clinical studies. In this manuscript, we have identified, summarized, and critically appraised tinnitus-related randomized clinical trials since 2010, aiming at systematically mapping the research conducted in this area. The results of our analysis of the 73 included randomized clinical trials provide important insight on the identification of limitations of previous works, methodological pitfalls or gaps in current knowledge, a prerequisite for the adequate interpretation of current literature and execution of future studies.

Keywords: randomized controlled trial; tinnitus; tinnitus treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Study selection PRISMA flow diagram.
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