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Review
. 2021 Apr 20;22(8):4255.
doi: 10.3390/ijms22084255.

Diffuse Idiopathic Skeletal Hyperostosis of Cervical Spine with Dysphagia-Molecular and Clinical Aspects

Mikołaj Dąbrowski  1 , Łukasz Kubaszewski  1
Affiliations
Review

Diffuse Idiopathic Skeletal Hyperostosis of Cervical Spine with Dysphagia-Molecular and Clinical Aspects

Mikołaj Dąbrowski et al. Int J Mol Sci. .

Abstract

Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by the calcification and ossification of the ligaments of the cervical spine; in some cases, it may result in dysphagia. The condition is more common in men over 50 years of age with metabolic disorders, and it is often asymptomatic and not a major issue for patients. The etiology of DISH is poorly understood, and known genetic factors indicate multiple signal pathways and multigene inheritance. In this review, we discuss the epidemiological, clinical, and etiological aspects of DISH with a special focus on dysphagia.

Keywords: DISH; DISHphagia; Forestier disease; cervical spine; diffuse idiopathic skeletal hyperostosis; dysphagia; molecular and genetical factors.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Potential role of polymorphism in diffuse idiopathic skeletal hyperostosis (DISH) and influence on regulatory pathways. Solid green arrows indicate activation; solid red bars indicate inhibition. Figure created using Servier Medical Art: https://smart.servier.com (accessed on 4 February 2021) [17].
Figure 2
Figure 2
Intraoperative fluoroscopic imaging before and after osteophyte removal in a 72-year-old patient with DISH with dysphagia.
See this image and copyright information in PMC

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References

    1. Resnick D., Niwayama G. Radiographic and pathologic features of spinal involvement in diffuse idiopathic skeletal hyperostosis (DISH) Radiology. 1976;119:559–568. doi: 10.1148/119.3.559. - DOI - PubMed
    1. Nascimento F.A., Gatto L.A., Lages R.O., Neto H.M., Demartini Z., Koppe G.L. Diffuse idiopathic skeletal hyperostosis: A review. Surg. Neurol. Int. 2014;5:122–125. doi: 10.4103/2152-7806.130675. - DOI - PMC - PubMed
    1. Vaishya R., Vijay V., Nwagbara I.C., Agarwal A.K. Diffuse idiopathic skeletal hyperostosis (DISH)—A common but less known cause of back pain. J. Clin. Orthop. Trauma. 2017;8:191–196. doi: 10.1016/j.jcot.2016.11.006. - DOI - PMC - PubMed
    1. Kuperus J.S., Mohamed Hoesein F.A.A., de Jong P.A., Verlaan J.J. Diffuse idiopathic skeletal hyperostosis: Etiology and clinical relevance. Best Pract. Res. Clin. Rheumatol. 2020;34:101527. doi: 10.1016/j.berh.2020.101527. - DOI - PubMed
    1. Mader R., Verlaan J.J., Buskila D. Diffuse idiopathic skeletal hyperostosis: Clinical features and pathogenic mechanisms. Nat. Rev. Rheumatol. 2013;9:741–750. doi: 10.1038/nrrheum.2013.165. - DOI - PubMed

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