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Review
. 2021 Apr 28;10(9):1911.
doi: 10.3390/jcm10091911.

Cervical Human Papillomavirus Infection (HPV) and High Oncogenic Risk Genotypes among Women Living with HIV in Asia: A Meta-Analysis

Florian Verrier  1   2   3 , Sophie Le Coeur  1   2   3 , Tristan Delory  1   2   3   4
Affiliations
Review

Cervical Human Papillomavirus Infection (HPV) and High Oncogenic Risk Genotypes among Women Living with HIV in Asia: A Meta-Analysis

Florian Verrier et al. J Clin Med. .

Abstract

Women living with HIV (WLHIV) are prone to harbor several high-risk human papillomavirus (HR-HPV) genotypes and to develop cervical cancerous lesions. Data on HPV prevalence in these women are needed to inform immunization programs, especially in Asia where few data are available. We conducted a systematic review and meta-analysis to estimate the prevalence of HPV and HR-HPV cervical infection in WLHIV in Asia and identify possible sources of heterogeneity for HR-HPV carriage. Pooled prevalence and its 95% confidence interval (95CI) were estimated using the inverse-variance weighting method. Linear regression weighted on study size was used to identify sources of heterogeneity. Among 7834 WLHIV (40 studies), the prevalence of HPV infection was 42.6% (95CI, 38.2% to 47.1%), and 34.6% (95CI, 30.3% to 39.1%) harbored HR-HPV genotypes, with significant heterogeneity across countries. In India, Thailand, and China, HPV-16 was the most frequent genotype (10.3%), followed by HPV-52 (5.4%), HPV-58 (5.0%), HPV-18 (4.1%), and HPV-33 (3.3%). In these women, most of whom were receiving antiretroviral therapy, we did not identify determinants of heterogeneity for HR-HPV infection. Our results underline the need for immunization programs based on nonavalent or new generation vaccines to prevent cervical cancer in WLHIV in Asia.

Keywords: Asia; HIV; HPV; meta-analysis; oncogenic HPV; prevalence; systematic review; women.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Process of selecting studies used in the meta-analysis.
Figure 2
Figure 2
Forest plot of HPV prevalence across countries in Asia. Meta-analyses with random-effects models. HPV: human papillomavirus; CI: confidence interval.
Figure 3
Figure 3
Forest plot of HR-HPV prevalence across China, India, and Thailand. Meta-analyses with random-effects models. HR-HPV: high-risk human papillomavirus; CI: confidence interval.
Figure 4
Figure 4
Prevalence of HR-HPV genotypes by country (China, India, and Thailand) and genus alpha group. HR-HPV: high-risk human papillomavirus. Each bar indicates the prevalence of the HPV genotype and its 95% confidence interval. Red bars for genus alpha-5 group, green bars for genus alpha-6, emerald green bars for genus alpha-7, blue bars for genus alpha-9, and purple bars for genus alpha-11.
See this image and copyright information in PMC

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