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Comment
. 2021 Jul;18(7):1628-1630.
doi: 10.1038/s41423-021-00650-7. Epub 2021 Apr 29.

Mucosal epithelial cells: the initial sentinels and responders controlling and regulating immune responses to viral infections

Jingyi Yang  1 , Huimin Yan  2
Affiliations
Comment

Mucosal epithelial cells: the initial sentinels and responders controlling and regulating immune responses to viral infections

Jingyi Yang et al. Cell Mol Immunol. 2021 Jul.
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Model of epithelial cells as initial responders that control and regulate immune responses to viral infections. A Upon viral infection, mucosal epithelial cells recognize viral PAMPs, activate various immune-associated genes, produce proteins such as defensins, cathelicidins, histatins, and type I and III interferons for antiviral defense, and secrete proinflammatory cytokines and chemokines as signals to attract and modulate hematopoietic immune cells (left). B Epithelial cells interact with interepithelial and subepithelial DCs to activate DCs, recruit innate immune cells such as natural killer (NK) cells, monocytes, and macrophages, and modulate the adhesion, activity, and function of these cells and immune responses to infection during acute inflammation (middle). C Finally, epithelial cells recruit and regulate adaptive immune cells by expressing soluble and cell-surface molecules that alter the function of DCs and further modulate the adhesion, cytokine secretion, cytolytic activity, and differentiation of T cells in the late state of infection. Furthermore, the differentiation and antibody secretion of B cells may also be modulated (right)
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Comment on

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