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Review
. 2021 Apr 8:2021:5534851.
doi: 10.1155/2021/5534851. eCollection 2021.

Update in the Management of ANCA-Associated Vasculitis: Recent Developments and Future Perspectives

Karla N Samman  1 , Carolyn Ross  1 , Christian Pagnoux  2 , Jean-Paul Makhzoum  1
Affiliations
Review

Update in the Management of ANCA-Associated Vasculitis: Recent Developments and Future Perspectives

Karla N Samman et al. Int J Rheumatol. .

Abstract

Significant progress has been made in the treatment of ANCA-associated vasculitides (AAV), notably in granulomatosis with polyangiitis and microscopic polyangiitis. Over the past few years, many innovative studies have changed the way we now induce and maintain remission in AAV; achieving remission while limiting treatment toxicity is the key. This article provides an in-depth, up-to-date summary of recent trials and suggests treatment algorithms for induction and maintenance of remission based on the latest guidelines. Future possible therapies in AAV will also be discussed.

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Conflict of interest statement

Dr. Pagnoux reports grants and personal fees from Roche, personal fees from ChemoCentryx, grants and personal fees from GSK, personal fees from Sanofi, personal fees from InflaRx GmbH, and personal fees from AstraZeneca, outside the submitted work; Dr. Makhzoum reports personal fees from Hoffmann-La Roche, outside the submitted work. The other authors have no conflicts of interest.

Figures

Figure 1
Figure 1
Timeline of hallmark trials of ANCA-associated vasculitis.
Figure 2
Figure 2
Suggested algorithm of induction therapy in severe GPA or MPA.
Figure 3
Figure 3
Suggested algorithm of maintenance therapy in severe GPA and MPA.
See this image and copyright information in PMC

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