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Review
. 2018 Jun 24;1(1):7-12.
doi: 10.1093/abt/tby002. eCollection 2018 Jun.

Enhancing antibody-dependent cell-mediated cytotoxicity: a strategy for improving antibody-based immunotherapy

David Zahavi  1 , Dalal AlDeghaither  1 , Allison O'Connell  1 , Louis M Weiner  1
Affiliations
Review

Enhancing antibody-dependent cell-mediated cytotoxicity: a strategy for improving antibody-based immunotherapy

David Zahavi et al. Antib Ther. .

Abstract

The targeting of surface antigens expressed on tumor cells by monoclonal antibodies (mAbs) has revolutionized cancer therapeutics. One mechanism of action of antibody-based immunotherapy is the activation of immune effector cells to mediate antibody-dependent cell-mediated cytotoxicity (ADCC). This review will summarize the process of ADCC, its important role in the efficacy of mAb therapy, how to measure it, and finally future strategies for antibody design that can take advantage of it to improve clinical performance.

Keywords: ADCC; Fc glycosylation; FcγR; immunotherapy; monoclonal antibody.

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Figures

Figure 1
Figure 1
Diagram of ADCC.
See this image and copyright information in PMC

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