Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May 28;42(5):663-671.
doi: 10.1093/carcin/bgab033.

The mitochondrial landscape of ovarian cancer: emerging insights

Pallavi Shukla  1   2 , Keshav K Singh  1
Affiliations
Review

The mitochondrial landscape of ovarian cancer: emerging insights

Pallavi Shukla et al. Carcinogenesis. .

Abstract

Ovarian cancer (OC) is known to be the most lethal cancer in women worldwide, and its etiology is poorly understood. Recent studies show that mitochondrial DNA (mtDNA) content as well as mtDNA and nuclear genes encoding mitochondrial proteins influence OC risk. This review presents an overview of role of mitochondrial genetics in influencing OC development and discusses the contribution of mitochondrial proteome in OC development, progression and therapy. A role of mitochondrial genetics in racial disparity is also highlighted. In-depth understanding of role of mitochondria in OC will help develop strategies toward prevention and treatment and improving overall survival in women with OC.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic diagram depicting role of key mitochondrial proteins involved in development, progression and drug resistant in OC.
See this image and copyright information in PMC

References

    1. Sharma, P., et al. (2019). Mitochondrial DNA integrity: role in health and disease. Cells, 8, 100. - PMC - PubMed
    1. Choudhury, A.R., et al. (2017) Mitochondrial determinants of cancer health disparities. Semin. Cancer Biol., 47, 125–146. - PMC - PubMed
    1. Signorile, A., et al. (2019). Human ovarian cancer tissue exhibits increase of mitochondrial biogenesis and cristae remodeling. Cancers, 11, 1350. - PMC - PubMed
    1. Bell, D.A. (2005) Origins and molecular pathology of ovarian cancer. Mod. Pathol., 18 (Suppl 2), S19–S32. - PubMed
    1. Rauh-Hain, J.A., et al. (2011) Ovarian cancer screening and early detection in the general population. Rev. Obstet. Gynecol., 4, 15–21. - PMC - PubMed

Publication types