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Meta-Analysis
. 2021 Jun;91(6):1251-1259.
doi: 10.1111/ans.16909. Epub 2021 Apr 29.

Antifibrinolytics reduces blood loss in thoracic surgery: a systematic review and meta-analysis

Lowell Leow  1 , Josiah Ng  2 , Hai Dong Luo  1 , Andrew M T L Choong  1   3   4 , Harish Mithiran  1 , Theo Kofidis  1 , John Kit Chung Tam  1   3
Affiliations
Meta-Analysis

Antifibrinolytics reduces blood loss in thoracic surgery: a systematic review and meta-analysis

Lowell Leow et al. ANZ J Surg. 2021 Jun.

Abstract

Background: The purpose of this systematic review is to evaluate the efficacy of antifibrinolytics in non-cardiac thoracic surgery.

Methods: We searched for all randomized controlled trials on this topic. A set of strict inclusion and exclusion criteria was developed. Six studies were meta-analysed together then in subgroups of topical tranexamic acid and intravenous aprotinin. We compared postoperative chest drain output, transfusions requirements and duration of hospital stay where available to determine the efficacy of topical tranexamic acid or intravenous aprotinin in reducing blood loss.

Results: The use of antifibrinolytics reduces 24-h chest drain output (-290.21 mL [-524.75, -55.66], P = 0.02, I2 = 98%), red blood cell transfusion requirements (-1.27 units [-2.24, -0.30], P = 0.01, I2 = 100%) and shortened duration of hospital stay (-1.81 days [-3.25, -0.36], P = 0.01, I2 = 96%). The subgroup analysis also supported this trend.

Conclusion: We conclude that the use of antifibrinolytics appears to reduce postoperative blood loss by reducing chest drain output, transfusion requirements and length of stay after thoracic surgery.

Keywords: antifibrinolytic; aprotinin; thoracic surgery; tranexamic acid.

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References

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