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. 2022 Feb;26(1):55-63.
doi: 10.1111/1744-9987.13665. Epub 2021 May 19.

Effect of dialyzer membranes on mortality in uremic patients undergoing long-term hemodialysis: A Nationwide population-based study using the Taiwan Dialysis Registry Data System 2005-2012

Chih-Yu Chang  1   2 , Mai-Szu Wu  3   4   5 , Chen-Hao Chang  6 , Chih-Chieh Lin  6 , Hsiang-Ling Lin  6 , Chih-Chin Kao  4   7 , Hsi-Hsien Chen  4   7 , Albert Li  8 , Chih-Cheng Hsu  9 , Yen-Chung Lin  4   7
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Effect of dialyzer membranes on mortality in uremic patients undergoing long-term hemodialysis: A Nationwide population-based study using the Taiwan Dialysis Registry Data System 2005-2012

Chih-Yu Chang et al. Ther Apher Dial. 2022 Feb.

Abstract

The characteristics in dialyzer are associated with mortality in patients with end-stage renal disease (ESRD) receiving hemodialysis (HD). This study is to investigate the effects of dialyzer membranes on 3-year mortality in ESRD patients. From the long-term nationwide population database. Prevalent HD patients during 2005-2012 were enrolled. Our main analysis to calculate the effect was cox regression multivariate model. Overall, the mean age of all population (N = 73 565) was 61.0 ± 13.6 years, the observation period is 2.46 years ±0.98 within 3 years and 64.6% used polysulfone (PS), polymethyl methacrylate (PMMA) (11.6%), polyethersulfone (11.4%), and cellulose triacetate (CTA) (10.7%), ethylene vinyl alcohol (EVAL) (hazard ratio [HR] 2.72, 95% confidence interval [CI] 1.71-4.33) and CTA (HR 1.35, 95% CI 1.12-1.64) were associated with higher mortality than PS, but PMMA was not. EVAL and CTA adversely affected mortality and PMMA had no protective role. Further investigations on membrane characters on HD patients are warranted. Taipei Medical University (TMU) (TMU-JIRB (No. N201804051).

Keywords: albumin; chronic hemodialysis; dialyzer membrane; nutrition; uremia toxin.

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