Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Nov;12(11):832-835.
doi: 10.1007/s13238-021-00847-6. Epub 2021 Apr 30.

Convergent evolution of SARS-CoV-2 in human and animals

Hang-Yu Zhou #  1   2 , Cheng-Yang Ji #  1   2 , Hang Fan  3 , Na Han  1   2 , Xiao-Feng Li  3 , Aiping Wu  4   5 , Cheng-Feng Qin  6
Affiliations

Convergent evolution of SARS-CoV-2 in human and animals

Hang-Yu Zhou et al. Protein Cell. 2021 Nov.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
Shared mutations of SARS-CoV-2 strains in mouse and human. (A) After passaging a patient isolated virus in mice for 36 passages, 12 mutations could be detected. Six mutations detected both in mice and circulated in humans were colored red while other mutations could only be detected in mice were colored black. For the red dots, the size of dots was related with the frequency of each mutations in humans. (B) The spatio-temporal distribution in humans of the viral strains with the six mutations detected both in mice and human collected in GISAID until Jan. 11th 2021. H470Y could be detected in patients in Asia, Europe, North America and South America. L37F could be detected in viruses all over the world. P84S could be identified mainly in Europe and North America. The K417N mutation could be detected earlier in Europe but not detected continuously, after Oct. this mutation was bursting with N501Y in Africa. The bursting of N501Y mutation in Africa and Europe since Sep. related with the observed pandemic caused by 501Y.V1 and 501Y.V2. The D128Y were mainly occurred in Europe and North America
See this image and copyright information in PMC

References

    1. Cockrell AS, Yount BL, Scobey T, Jensen K, Douglas M, Beall A, Tang X-C, Marasco WA, Heise MT, Baric RS. A mouse model for MERS coronavirus-induced acute respiratory distress syndrome. Nat Microbiol. 2016;2:1–11. - PMC - PubMed
    1. Chinese SARS Molecular Epidemiology Consortium Molecular evolution of the SARS coronavirus during the course of the SARS epidemic in China. Science. 2004;303:1666–1669. doi: 10.1126/science.1092002. - DOI - PubMed
    1. Davies NG, Barnard RC, Jarvis CI, Kucharski AJ, Munday J, Pearson CA, Russell TW, Tully DC, Abbott S, Gimma A (2020) Estimated transmissibility and severity of novel SARS-CoV-2 Variant of Concern 202012/01 in England. medRxiv.
    1. Elbe S, Buckland-Merrett G. Data, disease and diplomacy: GISAID’s innovative contribution to global health. Glob Chall. 2017;1:33–46. doi: 10.1002/gch2.1018. - DOI - PMC - PubMed
    1. Grubaugh ND, Petrone ME, Holmes EC. We shouldn’t worry when a virus mutates during disease outbreaks. Nat Microbiol. 2020;5:529–530. doi: 10.1038/s41564-020-0690-4. - DOI - PMC - PubMed

Publication types

Substances