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Comment
. 2021 Apr 29;184(9):2276-2278.
doi: 10.1016/j.cell.2021.04.009.

SARS-CoV-2 RNA: Exclusive friends and common foes

Emmanuelle V LeBlanc  1 , Che C Colpitts  2
Affiliations
Comment

SARS-CoV-2 RNA: Exclusive friends and common foes

Emmanuelle V LeBlanc et al. Cell. .

Abstract

Infection with SARS-CoV-2 sets off a molecular arms race between virus replication and host cell defense. In this issue of Cell, Flynn, Belk, et al. integrate an advanced large-scale RNA-centered approach with custom CRISPR screens to functionally characterize the interactome of the SARS-CoV-2 RNA genome during infection.

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Figures

Figure 1
Figure 1
Insights from SARS-CoV-2 RNA-host protein interactome Comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) in SARS-CoV-2-susceptible cells lines (left) was leveraged to identify host factors that bind the viral RNA genome during active infection. Integration of these findings with ChIRP-MS data for other RNA viruses and functional screens by targeted CRISPR approaches resulted in several key findings (right).
See this image and copyright information in PMC

Comment on

  • Discovery and functional interrogation of SARS-CoV-2 RNA-host protein interactions.
    Flynn RA, Belk JA, Qi Y, Yasumoto Y, Wei J, Alfajaro MM, Shi Q, Mumbach MR, Limaye A, DeWeirdt PC, Schmitz CO, Parker KR, Woo E, Chang HY, Horvath TL, Carette JE, Bertozzi CR, Wilen CB, Satpathy AT. Flynn RA, et al. Cell. 2021 Apr 29;184(9):2394-2411.e16. doi: 10.1016/j.cell.2021.03.012. Epub 2021 Mar 11. Cell. 2021. PMID: 33743211 Free PMC article.

References

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