The imitation game: How glioblastoma outmaneuvers immune attack
- PMID: 33930294
- DOI: 10.1016/j.cell.2021.04.008
The imitation game: How glioblastoma outmaneuvers immune attack
Abstract
Immune evasion and resistance to immunotherapy mark major roadblocks in treating glioblastoma, the deadliest form of brain cancer. In this issue of Cell, Gangoso et al. demonstrate that the immune microenvironment drives glioblastoma cells to hijack myeloid-characteristic transcriptional and epigenetic circuits as a mode of immune evasion.
Copyright © 2021 Elsevier Inc. All rights reserved.
Conflict of interest statement
Declaration of interests M.G.F. receives consulting fees from the company 28/7. This is in no way related to this work presented here.
Comment on
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Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.Cell. 2021 Apr 29;184(9):2454-2470.e26. doi: 10.1016/j.cell.2021.03.023. Epub 2021 Apr 14. Cell. 2021. PMID: 33857425 Free PMC article.
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