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Comment
. 2021 Apr 29;184(9):2281-2283.
doi: 10.1016/j.cell.2021.04.007.

Here to stay: Writing lasting epigenetic memories

Hagar F Moussa  1 , James F Angstman  1 , Ahmad S Khalil  2
Affiliations
Free article
Comment

Here to stay: Writing lasting epigenetic memories

Hagar F Moussa et al. Cell. .
Free article

Abstract

In this issue of Cell, Nuñez et al. develop CRISPRoff, a programmable epigenetic memory writer capable of establishing specific gene silencing programs that are stably maintained across cell division and differentiation. The singular dCas9 fusion offers a simple, reliable, and general tool for genome-wide screens, multiplexed editing, and potential therapeutics.

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Conflict of interest statement

Declaration of interests A.S.K. is a co-founder of Fynch Biosciences and K2 Biotechnologies and is a scientific advisor for Senti Biosciences and Chroma Medicine.

Comment on

  • Genome-wide programmable transcriptional memory by CRISPR-based epigenome editing.
    Nuñez JK, Chen J, Pommier GC, Cogan JZ, Replogle JM, Adriaens C, Ramadoss GN, Shi Q, Hung KL, Samelson AJ, Pogson AN, Kim JYS, Chung A, Leonetti MD, Chang HY, Kampmann M, Bernstein BE, Hovestadt V, Gilbert LA, Weissman JS. Nuñez JK, et al. Cell. 2021 Apr 29;184(9):2503-2519.e17. doi: 10.1016/j.cell.2021.03.025. Epub 2021 Apr 9. Cell. 2021. PMID: 33838111 Free PMC article.

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