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Review
. 2021 Oct:166:103342.
doi: 10.1016/j.critrevonc.2021.103342. Epub 2021 Apr 28.

Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments

Paul Gougis  1 , Marc Hilmi  2 , Arthur Geraud  3 , Olivier Mir  4 , Christian Funck-Brentano  2
Affiliations
Free article
Review

Potential cytochrome P450-mediated pharmacokinetic interactions between herbs, food, and dietary supplements and cancer treatments

Paul Gougis et al. Crit Rev Oncol Hematol. 2021 Oct.
Free article

Abstract

Herbs, food and dietary supplements (HFDS), can interact significantly with anticancer drug treatments via cytochrome p450 isoforms (CYP) CYP3A4, CYP2D6, CYP1A2, and CYP2C8. The objective of this review was to assess the influence of HFDS compounds on these cytochromes. Interactions with CYP activities were searched for 189 herbs and food products, 72 dietary supplements in Web of Knowledge® databases. Analyses were made from 140 of 3125 clinical trials and 236 of 3374 in vitro, animal model studies or case reports. 18 trials were found to report direct interactions between 9 HFDS with 8 anticancer drugs. 21 HFDS were found to interact with CYP3A4, a major metabolic pathway for many anticancer drugs. All 261 HFDS were classified for their interaction with the main cytochromes P450 involved in the metabolism of anticancer drugs. We provided an easy-to-use colour-coded table to easily match potential interactions between 261 HFDS and 117 anticancer drugs.

Keywords: Anticancer drugs; Cytochromes; Dietary supplements; Food-drug interaction; Herb-drug interaction; Oncology; Pharmacokinetics.

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