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. 2021 Apr 30;14(1):10.
doi: 10.1186/s13044-021-00101-5.

Thyroid hemiagenesis with a TI-RADS 2 nodule in the contralateral lobe

Senai Goitom Sereke  1 , Anthony Oriekot  2 , Felix Bongomin  3   4
Affiliations

Thyroid hemiagenesis with a TI-RADS 2 nodule in the contralateral lobe

Senai Goitom Sereke et al. Thyroid Res. .

Abstract

Background: Thyroid hemiagenesis is a rare congenital anomaly in which one lobe of the thyroid gland fails to develop. There is an increased incidence of associated thyroid disorders in patients with thyroid hemiagenesis.

Case presentation: A 32-year-old Ugandan woman presented with a complaint of painless neck swelling of 3-months duration. The swelling was associated with a globus sensation. There was no history of thyroid - related problems or treatment prior to this presentation. Physical examination demonstrated a mobile right thyroid swelling without an obvious nodular contour. Neck ultrasound showed an absent left lobe of thyroid gland, a right lobe with a solitary nodule scoring two points on the Thyroid Imaging, Reporting and Data System (TI-RADS) and an isthmus in situ. Extensive search for possible ectopic thyroid tissue was negative. She was biochemically euthyroid. The patient was counseled about thyroid hemiagenesis and was put on a regular follow up in the clinic for the TI-RADS 2 nodule.

Conclusion: Thyroid hemiagenesis is often associated with other thyroid disorders. Its diagnosis should prompt an active search for other associated morphological or functional thyroid abnormalities.

Keywords: Hemiagenesis; Neck ultrasound; Nodule; TI-RADS; Thyroid.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Ultrasound of the thyroid gland with high frequency linear probe  demonstrating a Absent left thyroid lobe b The right thyroid lobe normal tissue volume, and  c Isthmus in situ both in longitudinal and transverse planes
Fig. 2
Fig. 2
Ultrasound of the right thyroid nodule a a well-defined nodule, with smooth margins, wider than taller, hypoechoic, spongiform composition, and with no echogenic foci b Color and spectral Doppler (triplex Doppler) of the nodule showing moderate and low resistance flow respectively
See this image and copyright information in PMC

References

    1. Szczepanek-Parulska E, Zybek-Kocik A, Wartofsky L, Ruchala M. Thyroid hemiagenesis: incidence, clinical significance, and genetic background. J Clin Endocrinol Metab. 2017;102(9):3124–37. 2017/07/02 ed. - PubMed
    1. Gurleyik E, Dogan S, Cetin F, Gursoy F, Ipor AM. Toxic adenoma in a patient with thyroid hemiagenesis. Cureus [Internet]. 9(9). [cited 2021 Mar 15]. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690428/. - PMC - PubMed
    1. Gordon J, Manley NR. Mechanisms of thymus organogenesis and morphogenesis. Dev Camb Engl. 2011;138(18):3865–78. - PMC - PubMed
    1. Bosco D, Cammarata A, Cannarella R, Latino R, Lanteri R, Di Cataldo A, et al. Thyroid hemiagenesis associated with multinodular goiter and Hashimoto’s thyroiditis. Il G Chir. 2018;15(6):291–4. - PMC - PubMed
    1. Mikosch P, Weixlbaumer V, Irrgang M, Aistleitner A, Trifina-Mikosch E. Hemiagenesis of the thyroid gland detected by coincidence—what is the clinical relevance? Wien Med Wochenschr. 2020;170(15):403–9. doi: 10.1007/s10354-020-00783-w. - DOI - PMC - PubMed

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