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Review
. 2021:125:259-274.
doi: 10.1016/bs.apcsb.2020.12.006. Epub 2021 Apr 10.

S1PR1 signaling in cancer: A current perspective

B Anu  1 , N N Namitha  1 , K B Harikumar  2
Affiliations
Review

S1PR1 signaling in cancer: A current perspective

B Anu et al. Adv Protein Chem Struct Biol. 2021.

Abstract

Sphingosine-1-phosphate receptor 1 (S1PR1) is a G-protein coupled receptor for the bioactive lysosphingolipid sphingosine 1-phosphate (S1P). S1PR1 belongs to the sphingosine-1-phosphate receptor subfamily comprising five members (S1PR1-5). It has prominent roles in regulating endothelial cell cytoskeletal structure, cell migration, immunomodulation, vasculogenesis during embryogenesis, T cell egress and Multiple sclerosis. This review is addressing the role of S1PR1 in tumorigenesis and therapeutic opportunities to target S1PR1 in cancer.

Keywords: Cancer; FTY720; Inflammation; Metastasis; Sphingosine kinase; Sphingosine-1-phosphate.

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