Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr;11(4):e386.
doi: 10.1002/ctm2.386.

Radionuclide molecular imaging of abdominal aortic aneurysms for risk stratification and non-invasive therapy assessment

Richa Gandhi  1 , Marc A Bailey  1 , Charalampos Tsoumpas  1
Affiliations

Radionuclide molecular imaging of abdominal aortic aneurysms for risk stratification and non-invasive therapy assessment

Richa Gandhi et al. Clin Transl Med. 2021 Apr.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Figures

FIGURE 1
FIGURE 1
In vivo imaging and structural stress of abdominal aortic aneurysms (AAA). Sagittal‐view (A) contrast‐enhanced CT and (B) [18F]FDG PET, with (C) structural stress plotted on 3D geometry. Transverse‐view (D) contrast‐enhanced CT and (E) [18F]FDG PET, with (F) structural stress plotted on the transverse plane. 13 Figure license: Huang et al., 2016. High structural stress andpresence of intraluminal thrombus predict abdominal aortic aneurysm 18F‐FDGuptake. This article is distributed under the terms of the Creative CommonsAttribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). Abbreviations: AAA, abdominal aortic aneurysm; CT, computed tomography; [18F]FDG, [18F]fluorodeoxyglucose; PET, positron emission tomography.
FIGURE 2
FIGURE 2
Ex vivo [18F]NaF micro‐PET/CT images and histology of aortic wall from (A) a patient without an aneurysm at post‐mortem and (B) a patient during open abdominal aortic aneurysm (AAA) repair. Regions of interest (dashed circle) of [18F]NaF uptake demonstrate (B1) atheromatous disease with necrosis (haematoxylin and eosin stain, magnification × 100) and (B2) calcification (black, Von Kossa stain, magnification × 200) in the AAA tissue that is not apparent in the control aorta (A1, A2). 6 Figure license: Forsythe et al., 2018. 18 F‐sodiumfluoride uptake in abdominal aortic aneurysms: The SoFIA 3 study. Thisarticle is distributed under the terms of the Creative Commons Attribution 4.0International License (https://creativecommons.org/licenses/by/4.0/). Abbreviations: AAA, abdominal aortic aneurysm; [18F]NaF, [18F]‐sodium fluoride; PET/CT, positron emission tomography/computed tomography.
FIGURE 3
FIGURE 3
Representative coronal‐view static [18F]FLT PET/CT images. White arrows indicate abdominal aortic location (short arrow, saline control; long arrow, abdominal aortic aneurysm [AAA]). 7 Figure license: Gandhi et al., 2019. Cell proliferation detectedusing [18F]FLT PET/CT as an early marker of abdominal aorticaneurysm. This article is distributed under the terms of the Creative CommonsAttribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). Abbreviations: [18F]FLT, [18F]fluorothymidine; PET/CT, positron emission tomography/computed tomography.
See this image and copyright information in PMC

References

    1. Sakalihasan N, Michel JB, Katsargyris A, et al. Abdominal aortic aneurysms. Nat Rev Dis Primers. 2018;4(1):34. - PubMed
    1. Nie M‐X, Zhang X‐H, Yan Y‐F, Zhao Q‐M. Relationship between inflammation and progression of an abdominal aortic aneurysm in a rabbit model based on 18F‐FDG PET/CT imaging. Vascular. 2018;26(6):571–580. - PubMed
    1. Barwick TD, Lyons OT, Mikhaeel NG, Waltham M, O'Doherty MJ. 18F‐FDG PET‐CT uptake is a feature of both normal diameter and aneurysmal aortic wall and is not related to aneurysm size. Eur J Nucl Med Mol Imaging. 2014;41(12):2310–2318. - PubMed
    1. Kuzniar M, Tegler G, Wanhainen A, Ahlstrom H, Mani K, Hansen T. Feasibility of assessing inflammation in asymptomatic abdominal aortic aneurysms with integrated 18F‐fluorodeoxyglucose positron emission tomography/magnetic resonance imaging. Eur J Vasc Endovasc Surg. 2020;59(3):464–471. - PubMed
    1. Li Z, Zhao Z, Cai Z, et al. Runx2 (runt‐related transcription factor 2)‐mediated microcalcification is a novel pathological characteristic and potential mediator of abdominal aortic aneurysm. Arterioscler Thromb Vasc Biol. 2020;40(5):1352–1369. - PubMed

Publication types

MeSH terms