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Comment
. 2021 May;23(5):1017-1019.
doi: 10.1111/jch.14205. Epub 2021 May 1.

The significance of plasma collagen degradation products as biomarkers for advanced hypertensive heart disease

Kevin Mani  1 , Arya Mani  2   3
Affiliations
Comment

The significance of plasma collagen degradation products as biomarkers for advanced hypertensive heart disease

Kevin Mani et al. J Clin Hypertens (Greenwich). 2021 May.
No abstract available

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Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Schematic of collagen synthesis and degradation are shown. Left panel shows high CITP levels generated by MMP1 degradation of collagen with fewer cross‐links compared to higher levels of cross‐link shown on the right. For abbreviations, please refer to the text.
See this image and copyright information in PMC

Comment on

References

    1. Prockop DJ, Kivirikko KI. Collagens: molecular biology, diseases, and potentials for therapy. Annu Rev Biochem. 1995;64:403‐34. - PubMed
    1. Lang C, Sauter M, Szalay G, et al. Connective tissue growth factor: a crucial cytokine‐mediating cardiac fibrosis in ongoing enterovirus myocarditis. J Mol Med (Berl). 2008;86(1):49‐60. - PubMed
    1. Lopez B, Gonzalez A, Ravassa S, et al. Circulating Biomarkers of Myocardial Fibrosis: The Need for a Reappraisal. J Am Coll Cardiol. 2015;65(22):2449‐56. - PubMed
    1. Querejeta R, Lopez B, Gonzalez A, et al. Increased collagen type I synthesis in patients with heart failure of hypertensive origin: relation to myocardial fibrosis. Circulation. 2004;110(10):1263‐8. - PubMed
    1. Romero CASM, Wasinski B, Reed B, et al. Angiotensin‐Converting Enzyme Inhibitors Increase Anti‐Fibrotic Biomarkers in African Americans with Left Ventricular Hypertrophy. J Clin Hypertens. 2021;23(5):1008‐16. - PMC - PubMed

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