Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 May 1;73(1):38.
doi: 10.1186/s43044-021-00161-w.

Clinical characteristics and outcomes of patients admitted with acute heart failure: insights from a single-center heart failure registry in South India

Aashiq Ahamed Shukkoor  1 , Nimmy Elizabeth George  1 , Shanmugasundaram Radhakrishnan  2 , Sivakumar Velusamy  3 , Rajendiran Gopalan  1 , Tamilarasu Kaliappan  1 , Premkrishna Anandan  1 , Ramasamy Palanimuthu  1 , Vidhyakar Balasubramaniam  1 , Vinoth Doraiswamy  1 , Arun Kaushik Ponnusamy  1
Affiliations

Clinical characteristics and outcomes of patients admitted with acute heart failure: insights from a single-center heart failure registry in South India

Aashiq Ahamed Shukkoor et al. Egypt Heart J. .

Abstract

Background: The epidemiology of HF in India is largely unexplored. Current resources are based on a few hospital-based and a community-based registry from North India. Thus, we present the data from a single hospital-based registry in South India. Patients admitted with acute heart failure over a period of 1 year were enrolled in the registry and were characterized based on their ejection fraction (EF) measured by echocardiogram. The clinical profile of the patients was assessed, including their in-hospital outcomes. One-way ANOVA and univariate analysis were performed for comparison between three EF-based groups and for the assessment of in-hospital outcomes.

Results: A total of 449 patients were enrolled in the registry, of which 296, 90, and 63 patients were categorized as, HFrEF, HFmrEF, and HFpEF, respectively. The prevalence of HFrEF was higher (65.99%). The mean age (SD) of the study cohort was 59.9±13.3. The majority of the patients presented with acute denovo HF (67%) and were more likely to be males (65.9%). The majority of patients presented with warm and wet clinical phenotype (86.4%). In hospital mortality was higher in HFmrEF (3.3%).

Conclusion: Patients with HFrEF had high adherence to guideline-directed medical therapy (GDMT). HFrEF patients were also likely to have longer hospital stay along with a worsening of renal function. The in-hospital mortality was comparable between the EF-based groups. Additionally, the association of clinical phenotypes with outcome highlighted that patients in warm and wet phenotype had a longer length of hospital stay, whereas the mortality and worsening renal function rates were found to be significantly higher in the cold and wet group.

Keywords: Heart failure; In-hospital; Mortalities; Registry.

PubMed Disclaimer

Conflict of interest statement

The author declares that there are no competing interests.

Figures

Fig. 1
Fig. 1
Usage of neurohormonal blockers. ACEI angiotensin-converting enzyme inhibitor, ARB angiotensin receptor blocker, ARNI angiotensin receptor neprilisin inhibitor, MRA minerelocorticoid reeceptor antagonist
Fig. 2
Fig. 2
Univariate analysis for mortality in patients admitted with heart failure. rEF reduced ejection fraction, mrEF mid-range ejection fraction, pEF preserved ejection fraction
See this image and copyright information in PMC

References

    1. Taylor CJ, Ordóñez-Mena JM, Roalfe AK, Lay-Flurrie S, Jones NR, Marshall T, et al. Trends in survival after a diagnosis of heart failure in the United Kingdom 2000-2017: population based cohort study. BMJ. 2019;364:I223. doi: 10.1136/bmj.I223. - DOI - PMC - PubMed
    1. Lee WC, Chavez YE, Baker T, Luce BR. Economic burden of heart failure: a summary of recent literature. Heart Lung. 2004;33(6):362–371. doi: 10.1016/j.hrtlng.2004.06.008. - DOI - PubMed
    1. Dokainish H, Teo K, Zhu J, Roy A, AlHabib KF, ElSayed A, et al. Global mortality variations in patients with heart failure: results from the international congestive heart failure (INTER-CHF) prospective cohort study. Lancet Glob Health. 2017;5(7):e665–e672. doi: 10.1016/S2214-109X(17)30196-1. - DOI - PubMed
    1. Panduranga P, Al-Zakwani I, SulaimanK A-HK, Alsheikh-Ali A, Al-Suwaidi J, et al. Comparison of Indian subcontinent and Middle East acute heart failure patients: results from the Gulf acute heart failure registry. Indian Heart J. 2016;68:36–44. doi: 10.1016/j.ihj.2015.11.019. - DOI - PMC - PubMed
    1. Chaturvedi V, Parakh N, Seth S, Bhargava B, Ramakrishnan S, Roy A, et al. Heart failure in India: the INDUS (INDiaUkieri study) study. J PractCardiovasc Sci. 2016;2:28–35.

LinkOut - more resources