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Meta-Analysis
. 2021 May 1;22(1):160.
doi: 10.1186/s12882-021-02351-9.

Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chronic kidney disease: a systematic review and meta-analysis

Siavash Fazelian  1 , Fatemeh Moradi  2 , Shahram Agah  3 , Akramsadat Hoseini  4 , Hafez Heydari  5 , Mojgan Morvaridzadeh  6 , Amirhosein Omidi  6 , Ana Beatriz Pizarro  7 , Atie Ghafouri  8 , Javad Heshmati  9
Affiliations
Meta-Analysis

Effect of omega-3 fatty acids supplementation on cardio-metabolic and oxidative stress parameters in patients with chronic kidney disease: a systematic review and meta-analysis

Siavash Fazelian et al. BMC Nephrol. .

Abstract

Background: Omega-3 fatty acids (FAs) have been suggested as a beneficial supplement in chronic kidney disease (CKD) patients, but the results of randomized clinical trials (RCTs) are controversial. We conducted a systematic review and meta-analysis to evaluate all the RCTs about the impact of omega-3 FAs supplementation on cardiometabolic outcomes and oxidative stress parameters in patients with CKD.

Methods: We performed a systematic database search in PubMed/MEDLINE, EMBASE, Scopus, Web of Science, and Cochrane Central, up to May 2020. We included all placebo-controlled randomized trials that assessed the effect of omega-3 FAs supplementation on any cardiometabolic outcomes: blood pressure, total cholesterol (TC), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) or triglycerides (TG) and oxidative stress parameters. Data were pooled using DerSimonian-Laird's random-effects model.

Results: Finally, thirteen articles met the inclusion criteria for this review omega-3 FAs supplementation significantly decrease TC (SMD: -0.26; 95% CI: - 0.51, - 0.02; I2 = 52.7%), TG (SMD: -0.22; 95% CI: - 0.43, - 0.02; I2 = 36.0%) and Malondialdehyde (MDA) levels (SMD: -0.91; 95% CI: - 1.29, - 0.54; I2 = 00.0%) and also significantly increase superoxide dismutase (SOD) (SMD: 0.58; 95% CI: 0.27, 0.90; I2 = 00.0%) and Glutathione peroxidase (GPx) (SMD: 0.50; 95% CI: 0.14, 0.86; I2 = 00.0%) activities. However our results show that omega-3 FAs supplementation have no significant effects on HDL, LDL and blood pressure. Conclusion This systematic review and meta-analysis supports current evidence for the clinical benefit of omega-3 FAs intake to improve cardiometabolic parameters in CKD patients. However, well-designed RCTs still needed to provide a conclusive picture in this field.

Keywords: Blood lipids; CKD; Cardio-metabolic outcomes; Omega-3 FAs; Oxidative stress.

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Conflict of interest statement

All authors declare no conflicts of interest.

Figures

Fig. 1
Fig. 1
PRISMA Flow diagram of study selection
Fig. 2
Fig. 2
Forest plot of the effect of omega-3 FAs supplementation on SBP (a) and DBP (b) in CKD patients
Fig. 3
Fig. 3
Forest plot of the effect of omega-3 FAs supplementation on TC (a) TG (b), HDL (c) and LDL (d) in CKD patients
Fig. 4
Fig. 4
Forest plot of the effect of omega-3 FAs supplementation on oxidative stress parameters; GPx(a), SOD (b) and MDA (c)
See this image and copyright information in PMC

References

    1. Wall R, Ross RP, Fitzgerald GF, Stanton C. Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr Rev. 2010;68(5):280–289. doi: 10.1111/j.1753-4887.2010.00287.x. - DOI - PubMed
    1. Khandouzi N, Shidfar F, Agah S, Hosseini AF, Dehnad A. Comparison of the effects of eicosapentaenoic acid and docosahexaenoic acid on the eradication of helicobacter pylori infection, serum inflammatory factors and total antioxidant capacity. Iranian journal of pharmaceutical research: IJPR. 2015;14(1):149–157. - PMC - PubMed
    1. Agah S, Shidfar F, Khandouzi N, Baghestani AR, Hosseini S. Comparison of the effects of eicosapentaenoic acid with docosahexaenoic acid on the level of serum lipoproteins in helicobacter pylori: A randomized clinical trial. Iran Red Crescent Med J. 2015;17(1):1–8. - PMC - PubMed
    1. Delgado-Lista J, Perez-Martinez P, Lopez-Miranda J, Perez-Jimenez F. Long chain omega-3 fatty acids and cardiovascular disease: a systematic review. Br J Nutr. 2012;107(S2):S201–S213. doi: 10.1017/S0007114512001596. - DOI - PubMed
    1. Potier L, Roussel R, Zeller M, Schiele F, Puymirat E, Simon T, Danchin N. Chronic kidney disease, diabetes, and risk of mortality after acute myocardial infarction: insight from the FAST-MI program. Diabetes Care. 2020;43(3):e43–e44. doi: 10.2337/dc19-2209. - DOI - PubMed

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