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Meta-Analysis
. 2021 May 1;10(1):75.
doi: 10.1186/s13756-021-00943-6.

The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis

Bahareh Hajikhani  1 , Mehdi Goudarzi #  1 , Sareh Kakavandi  1 , Sana Amini  1 , Samira Zamani  1 , Alex van Belkum  2 , Hossein Goudarzi  1 , Masoud Dadashi  3   4
Affiliations
Meta-Analysis

The global prevalence of fusidic acid resistance in clinical isolates of Staphylococcus aureus: a systematic review and meta-analysis

Bahareh Hajikhani et al. Antimicrob Resist Infect Control. .

Abstract

Background and aim: Staphylococcus aureus (S. aureus) is one of the most common pathogens causing nosocomial and community-acquired infections with high morbidity and mortality rates. Fusidic acid has been increasingly used for the treatment of infections due to methicillin-susceptible S. aureus (MSSA) and methicillin-resistant S. aureus (MRSA). The present study aimed to determine the precise prevalence of fusidic acid resistant MRSA (FRMRSA), fusidic acid resistant MSSA (FRMSSA), and total fusidic acid resistant S. aureus (FRSA) on a global scale.

Methods: Several international databases including Medline, Embase, and the Web of Sciences were searched (2000-2020) to discern studies addressing the prevalence of FRSA, FRMRSA, and FRMSSA. STATA (version14) software was used to interpret the data.

Results: Of the 1446 records identified from the databases, 215 studies fulfilled the eligibility criteria for the detection of FRSA (208 studies), FRMRSA (143 studies), and FRMSSA (71 studies). The analyses manifested that the global prevalence of FRSA, FRMRSA, and FRMSSA was 0.5%, 2.6% and 6.7%, respectively.

Conclusion: This meta-analysis describes an increasing incidence of FRSA, FRMSSA, and FRMRSA. These results indicate the need for prudent prescription of fusidic acid to stop or diminish the incidence of fusidic acid resistance as well as the development of strategies for monitoring the efficacy of fusidic acid use.

Keywords: Fusidic acid; MRSA; Meta-analysis; Staphylococcus aureus.

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Conflict of interest statement

AVB is an employee of bioMérieux, a French company developing diagnostic tools for infectious diseases. The company has had no influence on the design and execution of the current study. No competing interests apply for the other authors.

Figures

Fig. 1
Fig. 1
Flow chart of study selection for inclusion in the systematic review and meta-analysis
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