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Review
. 2021 Aug;1866(8):158961.
doi: 10.1016/j.bbalip.2021.158961. Epub 2021 Apr 30.

Circadian control of brown adipose tissue

Maaike E Straat  1 , Rick Hogenboom  1 , Mariëtte R Boon  1 , Patrick C N Rensen  1 , Sander Kooijman  2
Affiliations
Review

Circadian control of brown adipose tissue

Maaike E Straat et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2021 Aug.

Abstract

Disruption of circadian (~24 h) rhythms is associated with an increased risk of cardiometabolic diseases. Therefore, unravelling how circadian rhythms are regulated in different metabolic tissues has become a prominent research focus. Of particular interest is brown adipose tissue (BAT), which combusts triglyceride-derived fatty acids and glucose into heat and displays a circannual and diurnal rhythm in its thermogenic activity. In this review, the genetic, neuronal and endocrine generation of these rhythms in BAT is discussed. In addition, the potential risks of disruption or attenuation of these rhythms in BAT, and possible factors influencing these rhythms, are addressed.

Keywords: Brown adipocytes; Cardiometabolic health; Circadian rhythm; Lipids; Shift work.

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