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. 2021 Aug:174:109741.
doi: 10.1016/j.apradiso.2021.109741. Epub 2021 Apr 23.

Production of 52Mn using a semi-automated module

Jennifer M Pyles  1 , Adriana V F Massicano  2 , Jean-Pierre Appiah  2 , Jennifer L Bartels  2 , Aaron Alford  1 , Suzanne E Lapi  3
Affiliations

Production of 52Mn using a semi-automated module

Jennifer M Pyles et al. Appl Radiat Isot. 2021 Aug.

Abstract

This work focused on the production and purification of the positron emitter 52Mn (t1/2 = 5.6 d) via the natCr(p,n)52Mn reaction, using a TR24 cyclotron and a semi-automated system for the purification of 52Mn. Based on two-column and three-column systems, the recovery of 52Mn was 79.7 ± 6.2% (n = 3) and 70.8 ± 3.3% (n = 3), with processing times of 6.9 ± 0.5 h and 8.2 ± 0.6 h, respectively.

Keywords: Chemistry; Chromium; Cr-52; Cyclotron; Cyclotron target design; DOTA; Fluidic system design; HPGe; ICP-MS; Mn; Mn-52; Positron; Production purification; Proton irradiation; Radioactivity Manganese-52; Radiochemistry; Radiology; Semi-automated system.

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