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. 2021 Oct 1;49(10):1769-1778.
doi: 10.1097/CCM.0000000000005055.

Association of Early Multiple Organ Dysfunction With Clinical and Functional Outcomes Over the Year Following Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study

Vijay Krishnamoorthy  1   2   3   4   5   6   7   8   9   10   11   12   13 , Nancy Temkin  4   5 , Jason Barber  4 , Brandon Foreman  6 , Jordan Komisarow  7 , Fred K Korley  8 , Daniel T Laskowitz  1   7   9 , Joseph P Mathew  1 , Adrian Hernandez  10 , John Sampson  7 , Michael L James  1   2   9   11 , Raquel Bartz  1   2   11 , Karthik Raghunathan  1   2   3   4   5   6   7   8   9   10   11   12   13 , Benjamin A Goldstein  12 , Amy J Markowitz  11 , Monica S Vavilala  13 ; and the Transforming Clinical Research and Knowledge in TBI (TRACK-TBI) Investigators
Affiliations

Association of Early Multiple Organ Dysfunction With Clinical and Functional Outcomes Over the Year Following Traumatic Brain Injury: A Transforming Research and Clinical Knowledge in Traumatic Brain Injury Study

Vijay Krishnamoorthy et al. Crit Care Med. .

Abstract

Objectives: Traumatic brain injury is a leading cause of death and disability in the United States. While the impact of early multiple organ dysfunction syndrome has been studied in many critical care paradigms, the clinical impact of early multiple organ dysfunction syndrome in traumatic brain injury is poorly understood. We examined the incidence and impact of early multiple organ dysfunction syndrome on clinical, functional, and disability outcomes over the year following traumatic brain injury.

Design: Retrospective cohort study.

Setting: Patients enrolled in the Transforming Clinical Research and Knowledge in Traumatic Brain Injury study, an 18-center prospective cohort study of traumatic brain injury patients evaluated in participating level 1 trauma centers.

Subjects: Adult (age > 17 yr) patients with moderate-severe traumatic brain injury (Glasgow Coma Scale < 13). We excluded patients with major extracranial injury (Abbreviated Injury Scale score ≥ 3).

Interventions: Development of early multiple organ dysfunction syndrome, defined as a maximum modified Sequential Organ Failure Assessment score greater than 7 during the initial 72 hours following admission.

Measurements and main results: The main outcomes were: hospital mortality, length of stay, 6-month functional and disability domains (Glasgow Outcome Scale-Extended and Disability Rating Scale), and 1-year mortality. Secondary outcomes included: ICU length of stay, 3-month Glasgow Outcome Scale-Extended, 3-month Disability Rating Scale, 1-year Glasgow Outcome Scale-Extended, and 1-year Disability Rating Scale. We examined 373 subjects with moderate-severe traumatic brain injury. The mean (sd) Glasgow Coma Scale in the emergency department was 5.8 (3.2), with 280 subjects (75%) classified as severe traumatic brain injury (Glasgow Coma Scale 3-8). Among subjects with moderate-severe traumatic brain injury, 252 (68%) developed early multiple organ dysfunction syndrome. Subjects that developed early multiple organ dysfunction syndrome had a 75% decreased odds of a favorable outcome (Glasgow Outcome Scale-Extended 5-8) at 6 months (adjusted odds ratio, 0.25; 95% CI, 0.12-0.51) and increased disability (higher Disability Rating Scale score) at 6 months (adjusted mean difference, 2.04; 95% CI, 0.92-3.17). Subjects that developed early multiple organ dysfunction syndrome experienced an increased hospital length of stay (adjusted mean difference, 11.4 d; 95% CI, 7.1-15.8), with a nonsignificantly decreased survival to hospital discharge (odds ratio, 0.47; 95% CI, 0.18-1.2).

Conclusions: Early multiple organ dysfunction following moderate-severe traumatic brain injury is common and independently impacts multiple domains (mortality, function, and disability) over the year following injury. Further research is necessary to understand underlying mechanisms, improve early recognition, and optimize management strategies.

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Conflict of interest statement

Drs. Krishnamoorthy’s and Foreman’s institutions received funding from the National Institutes of Health (NIH). Drs. Krishnamoorthy, Temkin, Foreman, Goldstein, and Vavilala received support for article research from the NIH. Dr. Temkin’s institution also received funding from the U.S. Federal Government; she received funding from several pharmaceutical companies and the University of Southern California. Dr. Foreman’s institution received funding from the National Institute of Neurological Disorders and Stroke, the Department of Defense, and the National Science Foundation; he received funding from UCB Pharma. The remaining authors have disclosed that they do not have any potential conflicts of interest.

Figures

Figure 1:
Figure 1:
STROBE diagram/flow
Figure 2:
Figure 2:
Distribution of SOFA scores over first 72 hours
Figure 3:
Figure 3:
Kaplan-Meier Curve for 1-year cumulative survival
Figure 4:
Figure 4:
GOSE distribution (3-month, 6-month, 1-year)
See this image and copyright information in PMC

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