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Meta-Analysis
. 2021 Apr 15:12:576619.
doi: 10.3389/fendo.2021.576619. eCollection 2021.

Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis

Klara Komici  1 , Antonio Dello Iacono  2 , Antonio De Luca  3 , Fabio Perrotta  1 , Leonardo Bencivenga  4   5 , Giuseppe Rengo  4   6 , Aldo Rocca  1 , Germano Guerra  1
Affiliations
Meta-Analysis

Adiponectin and Sarcopenia: A Systematic Review With Meta-Analysis

Klara Komici et al. Front Endocrinol (Lausanne). .

Abstract

Background: Sarcopenia is a progressive loss of skeletal muscle mass whose pathophysiology has been proposed to possibly involve mechanisms of altered inflammatory status and endocrine function. Adiponectin has been shown to modulate inflammatory status and muscle metabolism. However, the possible association between adiponectin levels and sarcopenia is poorly understood. In order to fill this gap, in the present manuscript we aimed to summarize the current evidence with a systematic review and a meta-analysis of studies reporting serum adiponectin levels in patients with sarcopenia compared to non-sarcopenic controls.

Methods: An electronic search through Medline/PubMed, Cochrane Library, and Science Direct was performed till March 1, 2020. From the included papers, meta-analysis of cross-sectional studies comparing serum levels of adiponectin between patients with sarcopenia and controls was performed.

Results: Out of 1,370 initial studies, seven studies were meta-analyzed. Sarcopenic participants had significantly higher levels of adiponectin Hedges' g with 95% confidence interval (CI): 1.20 (0.19-2.22), p = 0.02 than controls. Subgroup analysis, performed in Asian population and focused on identification of the condition based on AWGS criteria, reported higher adiponectin levels in sarcopenic population (2.1 (0.17-4.03), p = 0.03 and I2 = 98.98%. Meta-regression analysis revealed female gender to significantly influence the results as demonstrated by beta = 0.14 (95% CI (0.010-0.280), p = 0.040).

Conclusions: Our meta-analysis found evidence that sarcopenia is associated with higher adiponectin levels. However, caution is warranted on the interpretation of these findings, and future longitudinal research is required to disentangle and better understand the topic.

Keywords: adiponectin; aging; elderly; muscle mass; sarcopenia.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of study selection.
Figure 2
Figure 2
Forest plot of serum adiponectin levels in sarcopenic vs. no sarcopenic subjects. SD, standard deviation; CI, confidence interval.
Figure 3
Figure 3
Forest plot of serum adiponectin levels in sarcopenic vs. no sarcopenic subjects. Studies performed on Asian population and or based on AWGS criteria. SD, standard deviation; CI, confidence interval.
Figure 4
Figure 4
Forest plot of serum adiponectin levels in sarcopenic vs. no sarcopenic subjects. Studies applying DXA. SD, standard deviation; CI, confidence interval.
See this image and copyright information in PMC

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