Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2020 Oct-Dec;15(4):370-374.
doi: 10.4103/jpn.JPN_133_19. Epub 2021 Jan 19.

Cerebral Venous Sinus Thrombosis in Children: A Study from a Tertiary Care Hospital of Eastern India

Shubhankar Mishra  1 , Ashok K Mallick  1 , Geeta Mohanty  1 , Priyabrata Nayak  1
Affiliations

Cerebral Venous Sinus Thrombosis in Children: A Study from a Tertiary Care Hospital of Eastern India

Shubhankar Mishra et al. J Pediatr Neurosci. 2020 Oct-Dec.

Abstract

Context: Cerebral venous sinus (sinovenous) thrombosis (CVST) in childhood is a rare, but under recognized, disorder, typically of multifactorial etiology, with neurologic sequelae apparent in up to 40% of survivors and mortality approaching 10%.

Aim: The aim of this study was to enlist the patients diagnosed as CVST younger than 14 years of age and to diagnose the etiology along with radiological correlation.

Settings and design: This prospective clinical study was conducted for 2 years in the Department of Neurology, Srirama Chandra Bhanja Medical College & Hospital (SCBMCH), Cuttack, Odisha, India.

Materials and methods: All the patients were enlisted in a prestructured format with detailed clinico-radiological evaluation. Treatment was performed according to recent guidelines. Outcome after 3 months was analyzed. Ethical clearance was obtained from institutional ethics committee.

Statistical analysis: Data were statistically analyzed using IBM SPSS Statistics for Windows, version 20 (IBM Corp., Armonk, N.Y., USA).

Results: The total number of patients included in the study was 30. Of them, six were neonates. The most common provocative factor was tuberculous meningitis. Phototherapy after neonatal hyperbilirubinemia was prominent cause in neonatal age group. Multiple sinus involvement was seen in most of the patients. Transverse sinus was the most common sinus to be involved.

Conclusion: CVST is an underdiagnosed but important cause of stroke in childhood, occurring most often in the neonatal period. Mortality and morbidity are significant. Infections hyper coagulative disorders are the two primary associations. Magnetic resonance venography is the investigation of choice. Early diagnosis with management along with plan for secondary prevention can save from catastrophic consequences.

Keywords: Cerebral venous sinus thrombosis; phototherapy; post-infective; transverse sinus.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
MRV—transverse sinus thrombosis with collaterals in a nephrotic syndrome child
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Ichord R. Cerebral sinovenous thrombosis. Front Pediatr. 2017;5:163. - PMC - PubMed
    1. Carducci C, Colafati GS, Figà-Talamanca L, Longo D, Lunardi T, Randisi F, et al. Cerebral sinovenous thrombosis (CSVT) in children: What the pediatric radiologists need to know. Radiol Med. 2016;121:329–41. - PubMed
    1. Moharir MD, Shroff M, Stephens D, Pontigon AM, Chan A, MacGregor D, et al. Anticoagulants in pediatric cerebral sinovenous thrombosis: A safety and outcome study. Ann Neurol. 2010;67:590–9. - PubMed
    1. Nagaraja D, Wassy M, Christopher M, Santosh V. Cerebral venous sinus thrombosis. In: Chopra JS, Sawhney IMS, editors. Neurology in tropics. 2nd ed. Chennai, India: Elsevier; 2016. pp. 669–79.
    1. Canhão P, Falcão F, Ferro JM. Thrombolytics for cerebral sinus thrombosis: A systematic review. Cerebrovasc Dis. 2003;15:159–66. - PubMed