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. 2021 Apr 15:2021:6693405.
doi: 10.1155/2021/6693405. eCollection 2021.

Serum Sulfhydryl Groups, Malondialdehyde, Uric Acid, and Bilirubin as Predictors of Adverse Outcome in Heart Failure Patients due to Ischemic or Nonischemic Cardiomyopathy

Celina Wojciechowska  1 , Wojciech Jacheć  1 , Ewa Romuk  2 , Anna Ciszek  3 , Patryk Bodnar  3 , Tomasz Chwalba  3 , Martyna Waliczek  4 , Mariusz Gąsior  5 , Piotr Rozentryt  4   5
Affiliations

Serum Sulfhydryl Groups, Malondialdehyde, Uric Acid, and Bilirubin as Predictors of Adverse Outcome in Heart Failure Patients due to Ischemic or Nonischemic Cardiomyopathy

Celina Wojciechowska et al. Oxid Med Cell Longev. .

Abstract

Oxidative stress plays a significant role in the pathogenesis of heart failure (HF). The aim of the study was to investigate the prognostic value of oxidation-reduction (redox) markers in patients with HF due to ischemic and nonischemic cardiomyopathy. The study included 707 patients of HF allocated into two groups depending on ethology: ischemic cardiomyopathy (ICM) (n = 435) and nonischemic cardiomyopathy (nICM) (n = 272), who were followed up for one year. The endpoint occurrence (mortality or heart transplantation) in a 1-year follow-up was similar in the ICM and nICM group. The predictive value of endpoint occurrence of oxidative stress biomarkers such as the serum protein sulfhydryl groups (PSH), malondialdehyde (MDA), uric acid (UA), bilirubin, and MDA/PSH ratio and other clinical and laboratory data were assessed in both groups (ICM and nICM) separately using univariate and multivariate Cox regression analyses. In multivariate analysis, the higher concentrations of UA (p = 0.015, HR = 1.024, 95% CI (1.005-1.044)) and MDA (p = 0.004, HR = 2.202, 95% CI (1.296-3.741)) were significantly associated with adverse prognosis in patients with ICM. Contrastingly, in patients with nICM, we observed that higher bilirubin concentration (p = 0.026, HR = 1.034, 95% CI (1.004-1.064)) and MDA/PSH ratio (p = 0.034, HR = 3.360, 95% CI (1.096-10.302)) were significantly associated with increased risk of death or HT. The results showed the association of different oxidative biomarkers on the unfavorable course of heart failure depending on etiology.

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Conflict of interest statement

The authors declare that there is no conflict of interests regarding the publication of this paper.

Figures

Figure 1
Figure 1
Kaplan-Meier curve of survival for the ICM group stratified by the MDA cutoff value of 1.9 μmol/L. Log rank test (p = 0.034).
Figure 2
Figure 2
Kaplan-Meier curve of survival for the ICM group stratified by the uric acid cutoff value of 550 μmol/L. Log rank test (p < 0.001).
Figure 3
Figure 3
Kaplan-Meier curve of survival for the nICM group stratified by the MDA/PSH cutoff value of 0.65. Log rank test (p = 0.032).
Figure 4
Figure 4
Kaplan-Meier curve of survival for the nICM group stratified by the bilirubin cutoff value of 19.5 μmol/L. Log rank test (p = 0.003).
See this image and copyright information in PMC

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