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Case Reports
. 2021 Mar 4;9(4):2281-2284.
doi: 10.1002/ccr3.4012. eCollection 2021 Apr.

Prenatal management of fetal goiter alternating between hypothyroidism and hyperthyroidism in a mother with Graves' disease

Hortense Didier-Mathon  1 , Hanane Bouchghoul  2 , Marie-Victoire Senat  2 , Jacques Young  3 , Dominique Luton  1   4
Affiliations
Case Reports

Prenatal management of fetal goiter alternating between hypothyroidism and hyperthyroidism in a mother with Graves' disease

Hortense Didier-Mathon et al. Clin Case Rep. .

Abstract

We present a rare documented case with consecutive hypo- and hyperthyroidism during fetal life. First, hypothyroidism was due to transplacental passage of antithyroid drugs. After the mother's thyroidectomy, fetal hyperthyroidism was due to transplacental passage of persistent anti-thyrotropin receptor antibodies. Fetal goiter disappeared after adjusting maternal treatment.

Keywords: endocrinology and metabolic disorders; fetal goiter; maternal Grave's disease; obstetrics and gynecology; prenatal management.

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Conflict of interest statement

None declared.

Figures

FIGURE 1
FIGURE 1
A, Thyroid peripheral hypervascularization in an axial ultrasound section at 22 weeks B, Thyroid central hypervascularization in an axial ultrasound section at 28 weeks and 6 days
FIGURE 2
FIGURE 2
A, Evolution of fetal thyroid diameter. B, Evolution of fetal thyroid circumference. C, Medication dosage of carbimazol (NMZ) and levothyroxine (L‐T4). FBS, fetal blood sample
See this image and copyright information in PMC

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