Diagnostic challenge of a cystic solid pseudopapillary tumor in pancreas: A case report

Abstract

A solid pseudopapillary tumor should be included in the differential diagnosis of every pancreatic cystic lesion. A constellation of microscopic morphology and immunohistochemistry, in addition to the clinical history, aids in reaching the correct diagnosis.

FIGURE 1

Noncontrast CT scan revealed unilocular cystic lesion in the tail of the pancreas attached to the spleen

FIGURE 2

A Cystic mass in the distal part of the pancreas adherent to spleen

FIGURE 3

Microscopic findings of SPT, A, Nests of tumor cells embedded in fibrous capsule. B, C, and D the nests were composed of round monomorphic neoplastic cells. The cytoplasm was clear to granulate and the nuclei were uniform. (Haematoxylineosin, original magnification x40 [A] ×100 [B] ×200 [C] ×400 [D])

FIGURE 4

Tumor cells show positivity for CD56 (×400)

FIGURE 5

A, Positivity of β‐catenin in the tumor cells B, Ecadherin is diffusely negative in the tumor cells C, positivity of Cyclin D1 in the tumor cells. D, Tumor cells express weak positivity for NSE (Immunohistochemistry, orginal magnification ×100 [A, B] ×200 [C, D])