Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Mar 15;9(4):2504-2506.
doi: 10.1002/ccr3.4059. eCollection 2021 Apr.

An unusual case of chronic lymphocytic leukemia with trisomy 12 presenting with prolymphocytic transformation and t(8;21)(q22;q22)

Mishi Bhushan  1 , Kirthi R Kumar  2
Affiliations

An unusual case of chronic lymphocytic leukemia with trisomy 12 presenting with prolymphocytic transformation and t(8;21)(q22;q22)

Mishi Bhushan et al. Clin Case Rep. .

Abstract

First report of t(8;21)(q22;q22) in a patient with CLL. RUNX1-RUNX1T1 fusion gene resulting from the translocation may have played a role in the prolymphocytic transformation.

Keywords: hematology; oncology.

PubMed Disclaimer

Conflict of interest statement

None.

Figures

FIGURE 1
FIGURE 1
Peripheral blood showing prolymphocytic transformation to CLL cells (1A) and bone marrow biopsy with transformation of CLL to prolymphocytic leukemia (1B)
FIGURE 2
FIGURE 2
Cytogenetics showed an abnormal male karyotype with six out of twenty metaphases showing a translocation between chromosomes 8 and 21 in addition to trisomy 12 (2A)
See this image and copyright information in PMC

References

    1. Reiniger L, Bödör C, Bognár Á, et al. Richter’s and prolymphocytic transformation of chronic lymphocytic leukemia are associated with high mRNA expression of activation‐induced cytidine deaminase and aberrant somatic hypermutation. Leukemia. 2006;20(6):1089‐1095. - PubMed
    1. Foucar K, Rydell RE. Richter’s syndrome in chronic lymphocytic leukemia. Cancer. 1980;46(1):118‐134. - PubMed
    1. Rana C, Sharma S, Agarwal M. Prolymphocytic and richter’s transformation in peripheral blood: a case report and review of literature. J Hematol. 2014;3(3):86‐88.
    1. Jaffe ES, Harris NL, Stein H, Vardiman JW. WHO classification of tumors of hematopoietic and lymphoid tissues. In: Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, eds. Pathology and genetics of tumors of hematopoietic and lymphoid tissues. Lyon, France: IARC Press; 2001.
    1. Rossi D, Gaidano G. Richter syndrome: pathogenesis and management. Semin Oncol. 2016;43(2):311‐319. - PubMed

LinkOut - more resources