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Review
. 2021 Apr;10(1):33-37.
doi: 10.15420/aer.2020.29.

Electrophysiological Substrate in Patients with Barlow's Disease

Pasquale Vergara  1 , Savino Altizio  1 , Giulio Falasconi  1 , Luigi Pannone  1 , Simone Gulletta  1 , Paolo Della Bella  1
Affiliations
Review

Electrophysiological Substrate in Patients with Barlow's Disease

Pasquale Vergara et al. Arrhythm Electrophysiol Rev. 2021 Apr.

Abstract

Mitral valve prolapse (MVP) is the most common valvular heart disease, affecting 2-3% of the general population. Barlow's disease is a clinical syndrome characterised by MVP. Initially thought a benign condition, MVP is now recognised as a cause of sudden cardiac death and ventricular arrhythmias. The development of new imaging techniques has contributed recently to the identification of novel risk factors. Catheter ablation of ventricular arrhythmias in patients affected by MVP is traditionally considered challenging. In this review, the authors summarise the evidence on arrhythmogenesis in the context of MVP, along with risk stratification of sudden cardiac death and the available treatment options, including new catheter ablation techniques.

Keywords: Ventricular arrhythmias; mitral prolapse; mitral valve disease; premature ventricular beats; sudden cardiac death; ventricular tachycardia.

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Conflict of interest statement

Disclosure: The authors have no conflicts of interest to declare.

Figures

Figure 1:
Figure 1:. Risk Stratification in Patients with Mitral Valve Prolapse
Figure 2:
Figure 2:. Activation Mapping and Ablation of Premature Ventricular Complexes Originating from the Body of the Postero-medial Papillary Muscle
See this image and copyright information in PMC

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