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Review
. 2021 Apr 15:11:625210.
doi: 10.3389/fcimb.2021.625210. eCollection 2021.

Gut Microbiota and Diarrhea: An Updated Review

Yunxia Li  1 , Siting Xia  1 , Xiaohan Jiang  1 , Can Feng  1 , Saiming Gong  1 , Jie Ma  1 , Zhengfeng Fang  2 , Jie Yin  1 , Yulong Yin  1   3
Affiliations
Review

Gut Microbiota and Diarrhea: An Updated Review

Yunxia Li et al. Front Cell Infect Microbiol. .

Abstract

Diarrhea is a common problem to the whole world and the occurrence of diarrhea is highly associated with gut microbiota, such as bacteria, fungi, and viruses. Generally, diarrheal patients or animals are characterized by gut microbiota dysbiosis and pathogen infections may lead to diarrheal phenotypes. Of relevance, reprograming gut microbiota communities by dietary probiotics or fecal bacteria transplantation are widely introduced to treat or prevent diarrhea. In this review, we discussed the influence of the gut microbiota in the infection of diarrhea pathogens, and updated the research of reshaping the gut microbiota to prevent or treat diarrhea for the past few years. Together, gut microbiota manipulation is of great significance to the prevention and treatment of diarrhea, and further insight into the function of the gut microbiota will help to discover more anti-diarrhea probiotics.

Keywords: diarrhea; fecal microbiota transplantation; gut microbiota; intestinal health; probiotics.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Gut microbiota and diarrhea: Bacteria, Fungus and Virus all mediate the occurrence of diarrhea. microbial intervention by prebiotics, probiotics and FMT can regulate the composition of the intestinal flora to prevent and improve the occurrence of diarrhea.
See this image and copyright information in PMC

References

    1. Ackermann M., Stecher B., Freed N. E., Songhet P., Hardt W. D., Doebeli M. (2008). Self-destructive cooperation mediated by phenotypic noise. Nature 454 (7207), 987–990. 10.1038/nature07067 - DOI - PubMed
    1. Androga G. O., Hart J., Foster N. F., Charles A., Forbes D., Riley T. V. (2015). Infection with Toxin A-Negative, Toxin B-Negative, Binary Toxin-Positive Clostridium difficile in a Young Patient with Ulcerative Colitis. J. Clin. Microbiol. 53 (11), 3702–3704. 10.1128/JCM.01810-15 - DOI - PMC - PubMed
    1. Antunes L. C., McDonald J. A., Schroeter K., Carlucci C., Ferreira R. B., Wang M., et al. (2014). Antivirulence activity of the human gut metabolome. MBio 5 (4), e01183–e01114. 10.1128/mBio.01183-14 - DOI - PMC - PubMed
    1. Aron-Wisnewsky J., Clément K., Nieuwdorp M. (2019). Fecal Microbiota Transplantation: a Future Therapeutic Option for Obesity/Diabetes? Curr. Diabetes Rep. 19 (8), 51. 10.1007/s11892-019-1180-z - DOI - PubMed
    1. Asahara T., Shimizu K., Nomoto K., Hamabata T., Ozawa A., Takeda Y. (2004). Probiotic bifidobacteria protect mice from lethal infection with Shiga toxin-producing Escherichia coli O157:H7. Infect. Immun. 72 (4), 2240–2247. 10.1128/iai.72.4.2240-2247.2004 - DOI - PMC - PubMed

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