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Review
. 2021 Apr 14:9:663528.
doi: 10.3389/fcell.2021.663528. eCollection 2021.

The Role of the Effects of Endoplasmic Reticulum Stress on NLRP3 Inflammasome in Diabetes

Shuangyu Lv  1 , Xiaotian Li  1 , Honggang Wang  1
Affiliations
Review

The Role of the Effects of Endoplasmic Reticulum Stress on NLRP3 Inflammasome in Diabetes

Shuangyu Lv et al. Front Cell Dev Biol. .

Abstract

Endoplasmic reticulum (ER) is an important organelle for the protein synthesis, modification, folding, assembly, and the transport of new peptide chains. When the folding ability of ER proteins is impaired, the accumulation of unfolded or misfolded proteins in ER leads to endoplasmic reticulum stress (ERS). The nucleotide-binding oligomerization domain-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome, can induce the maturation and secretion of interleukin-1beta (IL-1β) and IL-18 through activating caspase-1. It is associated with many diseases. Studies have shown that ERS can regulate NLRP3 inflammasome in many diseases including diabetes. However, the mechanism of the effects of ERS on NLRP3 inflammasome in diabetes has not been fully understood. This review summarizes the recent researches about the effects of ERS on NLRP3 inflammasome and the related mechanism in diabetes to provide ideas for the relevant basic research in the future.

Keywords: NLRP3 inflammasome; diabetes; diabetic encephalopathy; diabetic nephropathy; endoplasmic reticulum stress.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The mechanism of activation of NLRP3 inflammasome by endoplasmic reticulum stress. ER, endoplasmic reticulum; NLRP3, NLRP3 inflammasome; ASC, apoptosis-related spot-like protein containing caspase recruitment domain; ERK1, extracellular signal regulated kinase 1; NF-κB, nuclear factor kappa B; ROS, reactive oxygen species; TXNIP, thioredoxin interacting protein; IL, interleukin.
See this image and copyright information in PMC

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