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. 2022 Dec;35(25):6593-6599.
doi: 10.1080/14767058.2021.1918091. Epub 2021 May 2.

Distinction between SGA and FGR by means of fetal umbilical vein flow and maternal hemodynamics

Daniele Farsetti  1   2 , Francesca Pometti  1   2 , Grazia Maria Tiralongo  2 , Damiano Lo Presti  2 , Ilaria Pisani  2 , Giulia Gagliardi  2 , Barbara Vasapollo  2 , Gian Paolo Novelli  3 , Herbert Valensise  1   2
Affiliations

Distinction between SGA and FGR by means of fetal umbilical vein flow and maternal hemodynamics

Daniele Farsetti et al. J Matern Fetal Neonatal Med. 2022 Dec.

Abstract

Objectives: To improve identification of fetal growth restriction (FGR) by means of umbilical venous flow (QUV) and maternal hemodynamics, including systemic vascular resistance (SVR) and cardiac output (CO), in order to distinguish between FGR and SGA.

Methods: We enrolled 68 pregnancies (36 SGA, 8 early FGR and 24 late FGR) who underwent a complete fetal hemodynamic examination including QUV and a noninvasive maternal hemodynamics assessment by means of USCOM.

Results: In comparison with SGA, QUV and corrected for estimated fetal weight QUV (cQUV) were significantly lower in early and late-FGR. In addition, maternal CO was lower in early and late-FGR, while SVR was lower only in early-onset FGR. According to ROC analysis, cQUV centile (AUC 0.92, 0.72) was the best parameter for the prediction of SGA before and after 32 weeks, followed by SVR and CO. For all parameters, the prediction was always better in the case of early-onset FGR <32 weeks.

Conclusions: UV flow and maternal hemodynamics examination are useful tools to accurately discern between SGA and FGR.

Keywords: Fetal growth restriction; cardiac output; maternal hemodynamics; small for gestational age; systemic vascular resistance; umbilical vein blood flow.

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