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Clinical Trial
. 2021 Jun;69(3):255-263.
doi: 10.1007/s12026-021-09196-2. Epub 2021 Apr 30.

Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection

Christian Selinger #  1   2 , Massilva Rahmoun #  3 , Carmen Lia Murall  3 , Claire Bernat  3 , Vanina Boué  3 , Marine Bonneau  4 , Christelle Graf  4 , Sophie Grasset  3 , Soraya Groc  3 , Jacques Reynes  5 , Christophe Hirtz  6 , Nathalie Jacobs  7 , Samuel Alizon  3
Affiliations
Clinical Trial

Cytokine response following perturbation of the cervicovaginal milieu during HPV genital infection

Christian Selinger et al. Immunol Res. 2021 Jun.

Abstract

Human papillomaviruses (HPVs) are oncogenic viruses causing most cervical cancers. Highly prevalent in young, sexually active women, only a minority of HPV infections persist. To better characterize the immuno-modulatory impact of early HPV infections, we measured changes in a panel of 20 cytokines in cervicovaginal samples collected from young women who were tested for HPV and self-reported for genital inflammation and infection symptoms. Multi-factor statistical analyses revealed that increased IL-1Alpha and IL-12/IL-23p40 concentrations were associated with HPV infection and that macrophage inflammatory proteins were associated in particular with high-risk HPV infections. ClinicalTrials.gov identifier NCT02946346.

Keywords: Cytokines; Human papillomavirus; Mucosal immunity; Natural history.

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