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Review
. 2022 Dec;29(6):3137-3151.
doi: 10.1007/s12350-021-02620-y. Epub 2021 Apr 30.

The current status of CZT SPECT myocardial blood flow and reserve assessment: Tips and tricks

Konstantin V Zavadovsky  1   2 , Andrew V Mochula  3 , Alina N Maltseva  3 , Vladimir V Shipulin  3 , Svetlana I Sazonova  3 , Marina O Gulya  3 , Ricardo Liga  4 , Alessia Gimelli  5
Affiliations
Review

The current status of CZT SPECT myocardial blood flow and reserve assessment: Tips and tricks

Konstantin V Zavadovsky et al. J Nucl Cardiol. 2022 Dec.

Abstract

Cardiac PET-derived measurements of myocardial blood flow (MBF) and myocardial flow reserve (MFR) are proven robust indexes of the severity of coronary artery disease (CAD). They facilitate the diagnosis of diffuse epicardial and microvascular disease and are also of prognostic significance. However, low availability and high cost have limited their wide clinical implementation. Over the last 15 years, cadmium zinc telluride (CZT)-based detectors have been implemented into SPECT imaging devices. Myocardial perfusion scintigraphy can be performed faster and with less radiation exposure as compared with standard gamma cameras. Rapid dynamic SPECT studies with higher count rates can be performed. This technological breakthrough has renewed the interest in SPECT MBF assessment in patients with CAD. Currently, two cardiac-centered CZT gamma cameras are available commercially-Discovery NM530c and D-SPECT. They differ in parameters such as collimator design, number of detectors, sensitivity, spatial resolution and image reconstruction. A number of publications have focused on the feasibility of dynamic CZT SPECT and on the correlation with cardiac PET and invasive coronary angiography measurements of fractional flow reserve. Current study reviews the present status of MBF and MFR assessment with CZT SPECT. It also aims to provide an overview of specific issues related to acquisition, processing and interpretation of quantitative studies in patients with CAD.

Keywords: CAD; CZT; Myocardial blood flow; Myocardial flow reserve; Myocardial ischemia; SPECT.

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References

    1. Driessen RS, Raijmakers PG, Stuijfzand WJ, Knaapen P. Myocardial perfusion imaging with PET. Int J Cardiovasc Imaging 2017;33:1021-31. https://doi.org/10.1007/s10554-017-1084-4 . - DOI
    1. Gullberg GT, Di Bella EV, Sinusas AJ. Estimation of coronary flow reserve: Can SPECT compete with other modalities? J Nucl Cardiol 2001;8:620-5. https://doi.org/10.1067/mnc.2001.118121 . - DOI
    1. Iida H, Eberl S, Kim K, Tamura Y, Ono Y, Nakazawa M, et al. Absolute quantitation of myocardial blood flow with 201Tl and dynamic SPECT in canine: Optimisation and validation of kinetic modelling. Eur J Nucl Med Mol Imaging 2008;35:896-905. https://doi.org/10.1007/s00259-007-0654-4 . - DOI
    1. Hsu B, Hu LH, Yang BH, Chen LC, Chen YK, Ting CH, et al. SPECT myocardial blood flow quantitation toward clinical use: A comparative study with (13)N-Ammonia PET myocardial blood flow quantitation. Eur J Nucl Med Mol Imaging 2017;44:117-28. https://doi.org/10.1007/s00259-016-3491-5 . - DOI
    1. Sugihara H, Yonekura Y, Kataoka K, Fukai D, Kitamura N, Taniguchi Y. Estimation of coronary flow reserve with the use of dynamic planar and SPECT images of Tc-99m tetrofosmin. J Nucl Cardiol 2001;8:575-9. https://doi.org/10.1067/mnc.2001.115934 . - DOI

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