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Comment
. 2021 Jun;41(6):439-441.
doi: 10.1002/cac2.12154. Epub 2021 May 3.

Metabolon: a novel cellular structure that regulates specific metabolic pathways

Tian Tian  1 , Jun Fan  1 , Shannon Elisabeth Elf  2
Affiliations
Comment

Metabolon: a novel cellular structure that regulates specific metabolic pathways

Tian Tian et al. Cancer Commun (Lond). 2021 Jun.

Abstract

This manuscript of research highlight focused on one paper recently published in Nature Metabolism entitled "Mitochondrial Long Non-coding RNA GAS5 Tunes TCA Metabolism in Response to Nutrient Stress" from Lin Aifu's group in Zhejiang University. In this manuscript, we discussed the novel findings in Lin's paper and concluded that the metabolon is emerging as a novel cellular structure that regulates specific metabolic pathways.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

FIGURE 1
FIGURE 1
GAS5 regulates FH‐MDH2‐CS complex formation and mitochondrial metabolism by increasing SIRT3‐mediated MDH2 deacetylation. Abbreviations: CS, citrate synthase; MDH2, malate dehydrogenase; FH, fumarate hydratase; TCA, tricarboxylic acid; GAS5, growth arrest‐specific transcript 5; Ac, acetylation; SIRT3, sirtuin 3
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