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Case Reports
. 2021 May 3;34(8):1045-1048.
doi: 10.1515/jpem-2020-0720. Print 2021 Aug 26.

An extremely high blood glucose level in a child with hyperglycemic hyperosmolar state and type 1 diabetes

Ivona Butorac Ahel  1 , Srecko Severinski  1 , Kristina Lah Tomulic  1 , Ana Milardovic  1 , Kristina Baraba Dekanic  1 , Dora Palcevski  2
Affiliations
Case Reports

An extremely high blood glucose level in a child with hyperglycemic hyperosmolar state and type 1 diabetes

Ivona Butorac Ahel et al. J Pediatr Endocrinol Metab. .

Abstract

Objectives: Hyperglycemic hyperosmolar state (HHS) is one of the most severe acute complications of diabetes mellitus (DM) characterized by severe hyperglycemia and hyperosmolality without significant ketosis and acidosis. What is new? Since HHS in the pediatric population is rare and potentially life-threatening, every reported case is very valuable for raising awareness among healthcare professionals.

Case presentation: A 7-year-old boy with previously diagnosed Joubert syndrome was admitted due to vomiting, polydipsia and polyuria started several days earlier. He was severely dehydrated, and the initial blood glucose level was 115 mmol/L. Based on clinical manifestations and laboratory results, he was diagnosed with T1DM and HHS. The treatment with intravenous fluid was started and insulin administration began later. He was discharged after 10 days without any complications related to HHS.

Conclusions: Since HHS has a high mortality rate, early recognition, and proper management are necessary for a better outcome.

Keywords: child; hyperglycemic hyperosmolar state; type 1 diabetes mellitus.

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References

    1. Wolfsdorf, JI, Glaser, N, Agus, M, Fritsch, M, Hanas, R, Rewers, A, et al.. ISPAD clinical practice consensus guidelines 2018: diabetic ketoacidosis and the hyperglycemic hyperosmolar state. Pediatr Diabetes 2018;19:155–77.
    1. Stoner, GD. Hyperosmolar hyperglycemic state. Am Fam Physician 2017;96:729–36.
    1. Cho, YM, Park, BS, Kang, MJ. A case report of hyperosmolar hyperglycemic state in a 7-year-old child: an unusual presentation of first appearance of type 1 diabetes mellitus. Medicine (Baltim) 2017;96:e7369.
    1. Zeitler, P, Haqq, A, Rosenbloom, A, Glaser, N, For the Drugs and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. Hyperglycemic hyperosmolar syndrome in children: pathophysiological considerations and suggested guidelines for treatment. J Pediatr 2011;158:9–14.
    1. Wetter, J, Gohlke, BC, Woelfle, JF. Hyperglycemic hyperosmolar state as initial manifestation of pediatric insulin-dependent diabetes. Klin Pädiatr 2012;224:32–3.

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