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. 2021 Jul:187:112762.
doi: 10.1016/j.phytochem.2021.112762. Epub 2021 Apr 30.

Bioactive sesterterpenoids from the fungus Penicillium roqueforti YJ-14

Jia-Peng Wang  1 , Yan Shu  1 , Rui Liu  1 , Jun-Li Gan  1 , Si-Ping Deng  1 , Xue-Yun Cai  1 , Jun-Tao Hu  1 , Le Cai  2 , Zhong-Tao Ding  3
Affiliations

Bioactive sesterterpenoids from the fungus Penicillium roqueforti YJ-14

Jia-Peng Wang et al. Phytochemistry. 2021 Jul.

Abstract

Seven previously undescribed sesterterpenes were characterized from Penicillium roqueforti YJ-14 by solid fermentation. Their structures were initially investigated in detail by spectroscopic analyses and HR-ESI-MS and were further confirmed by X-crystallography. In in vitro bioassays, compounds 1, 5 and 7 showed cytotoxic activity against the MCF-7 breast cancer cell line with IC50 values of 7.98 ± 0.93, 6.42 ± 0.41 and 7.32 ± 0.18 μM, respectively. Compounds 5 and 7 displayed significant cytotoxicity against the A549 lung cancer cell line (IC50 values of 4.83 ± 0.22 μM and 4.58 ± 0.85 μM, respectively). In addition, compound 5 showed an obvious inhibitory effect on nitric oxide production in LPS-activated RAW264.7 macrophages with an IC50 value of 9.53 ± 0.16 μM.

Keywords: Anti-inflammatory; Cytotoxicity; Peniroquesine; Sesterterpenoid.

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