Circadian Biology and Stroke

Eng H Lo^{1

2}, Gregory W Albers^{1

3}, Martin Dichgans^{1

4

5}, Geoffrey Donnan^{1

6}, Elga Esposito^{1

2}, Russell Foster^{1

7}, David W Howells^{1

8}, Yi-Ge Huang^{1

9}, Xunming Ji^{1

10}, Elizabeth B Klerman^{1

11}, Sarah Lee^{1

3}, Wenlu Li^{1

2}, David S Liebeskind^{1

12}, Ignacio Lizasoain^{1

13}, Emiri T Mandeville^{1

2}, Maria A Moro^{1

14}, MingMing Ning^{1

11}, David Ray^{1

15}, Sava Sakadžić^{1

2}, Jeffrey L Saver^{1

12}, Frank A J L Scheer^{1

16}, Magdy Selim^{1

17}, Steffen Tiedt^{1

5}, Fang Zhang^{1

2}, Alastair M Buchan^{1

9}

Affiliations

¹ CIRCA consortium (E.H.L., G.W.A., M.D., G.D., E.E., R.F., D.W.H., Y-G.H., X.J., E.B.K., S.L., W.L., D.S.L., I.L., E.T.M., M.A.M., M.N., D.R., S.S., J.L.S., F.A.J.L.S., M.S., S.T., F.Z., A.M.B.), Massachusetts General Hospital, Harvard Medical School, Boston.
² Departments of Radiology (E.H.L., E.E., W.L., E.T.M., S.S., F.Z.), Massachusetts General Hospital, Harvard Medical School, Boston.
³ Department of Neurology, Stanford Stroke Center, Stanford University, Palo Alto (G.W.A., S.L.).
⁴ German Center for Neurodegenerative Diseases (DZNE, Munich) and Munich Cluster for Systems Neurology (SyNergy), Germany (M.D.).
⁵ Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany (M.D., S.T.).
⁶ Departments of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Australia (G.D.).
⁷ Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences (R.F.), University of Oxford, United Kingdom.
⁸ Tasmanian School of Medicine, University of Tasmania, Australia (D.W.H.).
⁹ Department of Stroke Medicine (Y.H., A.M.B.), University of Oxford, United Kingdom.
¹⁰ Beijing Institute for Brain Disorders, China (X.J.).
¹¹ Neurology (E.B.K., M.N.), Massachusetts General Hospital, Harvard Medical School, Boston.
¹² Department of Neurology, Geffen School of Medicine, University of California Los Angeles (J.L.S., D.S.L.).
¹³ Department of Pharmacology and Toxicology, Complutense Medical School, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain (I.L.).
¹⁴ Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain (M.A.M.).
¹⁵ NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, and Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, United Kingdom (D.R.).
¹⁶ Departments of Medicine and Neurology, Brigham & Women's Hospital (F.A.J.L.S.), Harvard Medical School, Boston.
¹⁷ Department of Neurology, Beth Israel Deaconess Medical Center (M.S.), Harvard Medical School, Boston.

PMID: 33940951
DOI: 10.1161/STROKEAHA.120.031742

Review

Circadian Biology and Stroke

Eng H Lo et al. Stroke. 2021 Jun.

. 2021 Jun;52(6):2180-2190.

doi: 10.1161/STROKEAHA.120.031742. Epub 2021 May 4.

Authors

Affiliations

¹ CIRCA consortium (E.H.L., G.W.A., M.D., G.D., E.E., R.F., D.W.H., Y-G.H., X.J., E.B.K., S.L., W.L., D.S.L., I.L., E.T.M., M.A.M., M.N., D.R., S.S., J.L.S., F.A.J.L.S., M.S., S.T., F.Z., A.M.B.), Massachusetts General Hospital, Harvard Medical School, Boston.
² Departments of Radiology (E.H.L., E.E., W.L., E.T.M., S.S., F.Z.), Massachusetts General Hospital, Harvard Medical School, Boston.
³ Department of Neurology, Stanford Stroke Center, Stanford University, Palo Alto (G.W.A., S.L.).
⁴ German Center for Neurodegenerative Diseases (DZNE, Munich) and Munich Cluster for Systems Neurology (SyNergy), Germany (M.D.).
⁵ Institute for Stroke and Dementia Research (ISD), University Hospital, LMU Munich, Germany (M.D., S.T.).
⁶ Departments of Medicine and Neurology, Royal Melbourne Hospital, University of Melbourne, Australia (G.D.).
⁷ Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences (R.F.), University of Oxford, United Kingdom.
⁸ Tasmanian School of Medicine, University of Tasmania, Australia (D.W.H.).
⁹ Department of Stroke Medicine (Y.H., A.M.B.), University of Oxford, United Kingdom.
¹⁰ Beijing Institute for Brain Disorders, China (X.J.).
¹¹ Neurology (E.B.K., M.N.), Massachusetts General Hospital, Harvard Medical School, Boston.
¹² Department of Neurology, Geffen School of Medicine, University of California Los Angeles (J.L.S., D.S.L.).
¹³ Department of Pharmacology and Toxicology, Complutense Medical School, Instituto de Investigación Hospital 12 de Octubre, Madrid, Spain (I.L.).
¹⁴ Centro Nacional de Investigaciones Cardiovasculares, CNIC, Madrid, Spain (M.A.M.).
¹⁵ NIHR Oxford Biomedical Research Centre, John Radcliffe Hospital, and Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, United Kingdom (D.R.).
¹⁶ Departments of Medicine and Neurology, Brigham & Women's Hospital (F.A.J.L.S.), Harvard Medical School, Boston.
¹⁷ Department of Neurology, Beth Israel Deaconess Medical Center (M.S.), Harvard Medical School, Boston.

PMID: 33940951
DOI: 10.1161/STROKEAHA.120.031742

Abstract

Circadian biology modulates almost all aspects of mammalian physiology, disease, and response to therapies. Emerging data suggest that circadian biology may significantly affect the mechanisms of susceptibility, injury, recovery, and the response to therapy in stroke. In this review/perspective, we survey the accumulating literature and attempt to connect molecular, cellular, and physiological pathways in circadian biology to clinical consequences in stroke. Accounting for the complex and multifactorial effects of circadian rhythm may improve translational opportunities for stroke diagnostics and therapeutics.

Keywords: biomarkers; circadian rhythm; immune system; ischemia; neuroprotection; sleep.

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Circadian Biology and Stroke

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Circadian Biology and Stroke

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